{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:07:51Z","timestamp":1771337271824,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Besides its crucial role in type I hypersensitivity reactions, IgE is involved in anti-parasite immunity. This role has been clearly demonstrated in both human and rat schistosomiasis, but remains controversial in the mouse. Since the cellular distribution of the high affinity IgE receptor, Fc\u03b5RI, differs in humans and mice, it might explain the differences in effector function of IgE between the two species. In humans, eosinophils and macrophages induce IgE-dependent cytotoxicity toward Schistosoma mansoni larvae, which involves Fc\u03b5RI in the case of eosinophils. In the present study, we have investigated the expression and function of Fc\u03b5RI in rat eosinophils and macrophages. We demonstrate, by flow cytometry, fluorescence microscopy, and Western blot analysis, that in rats, as in humans, a functional \u03b1\u03b32 trimeric Fc\u03b5RI is expressed on eosinophils and macrophages. We also show that these two cell types can induce IgE-mediated, Fc\u03b5RI-dependent cellular cytotoxicity toward schistosomula. These results thus provide a molecular basis for the differences observed between rat and mouse regarding IgE-mediated anti-parasite immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.165.3.1266","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:16:28Z","timestamp":1398186988000},"page":"1266-1271","source":"Crossref","is-referenced-by-count":47,"title":["Expression of a Functional Fc\u03b5RI on Rat Eosinophils and Macrophages"],"prefix":"10.1093","volume":"165","author":[{"given":"David","family":"Dombrowicz","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et Recherche Me\u0301dicale, Unite\u0301 167, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Quatannens","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8526, Institut de Biologie de Lille , Lille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Papin","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et Recherche Me\u0301dicale, Unite\u0301 167, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre\u0301","family":"Capron","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et Recherche Me\u0301dicale, Unite\u0301 167, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Capron","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et Recherche Me\u0301dicale, Unite\u0301 167, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2026020213074064800_R1","first-page":"457","volume-title":"Annu. 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