{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:57:03Z","timestamp":1777395423403,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Functional immaturity of neonatal T cells is related to their immature phenotype, with the majority of neonatal T cells of naive (CD45RA+) T cells. The progression of T cells from naive cells to effector cells is dependent on the survival of Ag-specific T cells and their resistance to apoptosis. In this study, we showed for the first time that insulin-like growth factor 1 (IGF-1) converted cord blood CD45RA+ T cells to CD45RO+ T cells and inhibited cord blood T cell apoptosis. We found cord blood T cells stimulated with PHA would result in gradual loss of CD45RA and gain of CD45RO expression. IGF-1 further increased the loss of CD45RA and enhanced CD45RO expression in PHA-stimulated cord blood T cells. In addition, IGF-1 prevented cord blood T cells from spontaneous apoptosis through a mechanism other than Fas\/FasL. In PHA-activated cord blood T cells, IGF-1 prevented both naive (CD45RA+) and memory\/mature (CD45RO+) T cells from apoptosis. Moreover, cord blood T cells cultured with IGF-1 and PHA had a higher resistance to anti-Fas-induced apoptosis as compared with PHA-activated cord blood T cells. IGF-1 also significantly inhibited PHA-induced Fas expression on cord blood T cells. These results demonstrate that IGF-1 promotes the maturation and maintains the survival of cord blood T cells. Its antiapoptotic effect in PHA-activated cord blood T cells may be mediated through the down-regulation of Fas expression.<\/jats:p>","DOI":"10.4049\/jimmunol.165.3.1331","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:16:28Z","timestamp":1398186988000},"page":"1331-1336","source":"Crossref","is-referenced-by-count":43,"title":["Insulin-Like Growth Factor 1 Promotes Cord Blood T Cell Maturation and Inhibits Its Spontaneous and Phytohemagglutinin-Induced Apoptosis Through Different Mechanisms"],"prefix":"10.1093","volume":"165","author":[{"given":"Wenwei","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital , Pokfulam, Hong Kong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pik-To","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital , Pokfulam, Hong Kong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lung","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital , Pokfulam, Hong Kong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2026020213071783800_R1","first-page":"267","volume-title":"Annu. 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Sci. USA","year":"1993"},{"key":"2026020213071783800_R20","first-page":"65","volume-title":"Vitam. Horm.","year":"1997"},{"key":"2026020213071783800_R21","first-page":"39","volume-title":"J. Immunol. Methods","year":"1995"},{"key":"2026020213071783800_R22","first-page":"1545","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020213071783800_R23","first-page":"131","volume-title":"Cytometry","year":"1996"},{"key":"2026020213071783800_R24","first-page":"1","volume-title":"Cytometry","year":"1998"},{"key":"2026020213071783800_R25","first-page":"512","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020213071783800_R26","first-page":"9879","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1999"},{"key":"2026020213071783800_R27","first-page":"63","volume-title":"J. Clin. Immunol.","year":"1997"},{"key":"2026020213071783800_R28","first-page":"2072","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020213071783800_R29","first-page":"427","volume-title":"J. Exp. 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