{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:57:29Z","timestamp":1789999049637,"version":"4.0.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-\u03b3 (Mig), and IFN-inducible T-cell \u03b1-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes. In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD). IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-\u03b3- or TNF-\u03b1-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants. Immunohistochemistry of skin affected by ACD revealed that &amp;gt;70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells. Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-\u03b3 and IL-4 and expressed moderate to high levels of CXCR3. Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-\u03b3 and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-\u03b3 alone. In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-\u03b3 and TNF-\u03b1 induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.<\/jats:p>","DOI":"10.4049\/jimmunol.165.3.1395","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:16:28Z","timestamp":1398186988000},"page":"1395-1402","source":"Crossref","is-referenced-by-count":90,"title":["IL-4 Enhances Keratinocyte Expression of CXCR3 Agonistic Chemokines"],"prefix":"10.1093","volume":"165","author":[{"given":"Cristina","family":"Albanesi","sequence":"first","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Scarponi","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavani","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Federici","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"De Pita\u0300","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Puddu","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata, IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2026020213063141400_R1","first-page":"675","volume-title":"Annu. 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