{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:29:30Z","timestamp":1790944170192,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The purpose of this study was to determine whether \u03b3\u03b4 T cells were able to regulate graft-vs-host (GVH) reactivity mediated by \u03b1\u03b2 T cells in murine recipients transplanted with MHC-mismatched marrow grafts. Studies were conducted using ex vivo-activated \u03b3\u03b4 T cells because this was a more clinically relevant strategy, and these cells have been shown to be capable of facilitating alloengraftment without causing GVH disease (GVHD). Coadministration of activated \u03b3\u03b4 T cells and naive \u03b1\u03b2 T cells at the time of bone marrow transplantation (BMT) significantly exacerbated GVHD when compared with naive \u03b1\u03b2 T cells alone. In contrast, when the administration of naive \u03b1\u03b2 T cells was delayed for 2 wk post-BMT, survival was significantly enhanced in mice transplanted with BM plus activated \u03b3\u03b4 T cells vs those given marrow cells alone. Mitigation of GVHD by activated \u03b3\u03b4 T cells occurred only at high doses (150 \u00d7 106) and was a unique property of \u03b3\u03b4 T cells, as activated \u03b1\u03b2 T cells were incapable of ameliorating the subsequent development of GVHD. Protection from GVHD was not due to the direct inhibition of naive \u03b1\u03b2 T cells by \u03b3\u03b4 T cells. Rather, \u03b3\u03b4 T cells mediated this effect indirectly through donor BM-derived \u03b1\u03b2 T cells that acted as the proximate regulatory population responsible for the decrease in GVH reactivity. Collectively, these data demonstrate that activated \u03b3\u03b4 T cells are capable of modulating the ability of MHC-incompatible nontolerant \u03b1\u03b2 T cells to cause GVHD after allogeneic BMT.<\/jats:p>","DOI":"10.4049\/jimmunol.165.3.1634","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:16:28Z","timestamp":1398186988000},"page":"1634-1640","source":"Crossref","is-referenced-by-count":36,"title":["Adoptively Transferred \u03b3\u03b4 T Cells Indirectly Regulate Murine Graft-Versus-Host Reactivity Following Donor Leukocyte Infusion Therapy in Mice"],"prefix":"10.1093","volume":"165","author":[{"given":"William R","family":"Drobyski","sequence":"first","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin , Milwaukee, WI 53226"},{"name":"Bone Marrow Transplant Program, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Vodanovic-Jankovic","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin , Milwaukee, WI 53226"},{"name":"Bone Marrow Transplant Program, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2026020213075246700_R1","first-page":"445","volume-title":"Bone Marrow Transplant.","year":"1988"},{"key":"2026020213075246700_R2","first-page":"2237","volume-title":"Blood","year":"1989"},{"key":"2026020213075246700_R3","first-page":"555","volume-title":"Blood","year":"1990"},{"key":"2026020213075246700_R4","first-page":"1436","volume-title":"Transplantation","year":"1995"},{"key":"2026020213075246700_R5","first-page":"268","volume-title":"Transplantation","year":"1995"},{"key":"2026020213075246700_R6","first-page":"703","volume-title":"J. 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