{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:10:15Z","timestamp":1792203015220,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cross-linking of the B cell Ag receptor (BCR) induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C (PLC)-\u03b32, which is involved in the activation of the phosphatidylinositol pathway. To assess the importance of PLC-\u03b32 in murine lymphopoiesis, the PLC-\u03b32 gene was inducibly ablated by using IFN-regulated Cre recombinase. Mice with a neonatally induced loss of PLC-\u03b32 function displayed reduced numbers of mature conventional B cells and peritoneal B1 cells and defective responses in vitro to BCR stimulation and in vivo to immunization with thymus-independent type II Ags. In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-\u03b32 is a critical component of BCR signaling pathways and is required to promote B cell development.<\/jats:p>","DOI":"10.4049\/jimmunol.165.4.1738","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:29:56Z","timestamp":1398025796000},"page":"1738-1742","source":"Crossref","is-referenced-by-count":132,"title":["Cutting Edge: Essential Role of Phospholipase C-\u03b32 in B Cell Development and Function"],"prefix":"10.1093","volume":"165","author":[{"given":"Ari","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University , Moriguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneo","family":"Inaba","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University , Moriguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Sekimata","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Fukushima Medical College , Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyasu","family":"Kaisho","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Ikehara","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University , Moriguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Fukushima Medical College , Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University , Moriguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,8,15]]},"reference":[{"key":"2026020213082630600_R1","first-page":"296","volume-title":"Curr. 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