{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:40:36Z","timestamp":1791276036106,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interaction of B lymphocytes with Th cells is a fundamental step in the establishment of humoral immunity, and recent evidence suggests that direct interaction between B lymphocytes and dendritic cells (DCs) is also an important prerequisite. Factors involved in the selective recruitment of Th cells and DCs by B lymphocytes are insufficiently defined. We set out to delineate the role of IL-16, the soluble ligand of CD4, which is expressed on Th cells and DCs. B lymphocytes express IL-16 mRNA and synthesize bioactive IL-16 protein, and IL-16 is expressed in lymph node follicles in situ. B lymphocyte supernatant efficiently induces migration of CD4+ Th cells, monocyte-derived DCs, and circulating blood DCs in nitrocellulose filter-based assays. Neutralization of IL-16 bioactivity strongly inhibits this migratory response, suggesting that IL-16 might be a major chemotactic factor derived from B cells. The present data further support the idea that IL-16 might have a role in the initiation of cellular as well as humoral immunity by mediating the cellular cross-talk among T lymphocytes, B cells, and DCs, leading to recruitment of these cell types at common anatomical sites.<\/jats:p>","DOI":"10.4049\/jimmunol.165.5.2474","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:58:09Z","timestamp":1398189489000},"page":"2474-2480","source":"Crossref","is-referenced-by-count":71,"title":["B Lymphocyte-Derived IL-16 Attracts Dendritic Cells and Th Cells"],"prefix":"10.1093","volume":"165","author":[{"given":"Arthur","family":"Kaser","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dunzendorfer","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix A","family":"Offner","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othmar","family":"Ludwiczek","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Enrich","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O","family":"Koch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W","family":"Cruikshank","sequence":"additional","affiliation":[{"name":"Pulmonary Center, Boston University School of Medicine , Boston, MA 01226"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J","family":"Wiedermann","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Tilg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Innsbruck , Innsbruck ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2026020213084961800_R1","first-page":"476","volume-title":"Immunol. 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