{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:52:51Z","timestamp":1790175171004,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-13 is a multifunctional lymphokine sharing a number of biological properties with IL-4. We previously observed that IL-4 shows angiogenic activities in vitro as well as in vivo. In this study we examined the effect of IL-13 on angiogenesis in vitro and in vivo and also the underlying mechanisms. Human IL-13 significantly stimulated the formation of tube-like structures in collagen gels by human microvascular endothelial cells and bovine aortic endothelial cells by about 3-fold over the controls in the absence of the cytokines. Administration of murine IL-13 led to neovascularization when implanted in the rat cornea. Coadministration of neutralizing mAb to the IL-4R inhibited both tubular morphogenesis in vitro and activation of STAT6 induced by IL-4 or IL-13. Both IL-4 and IL-13 markedly increased mRNA levels of VCAM-1 in vascular endothelial cells, and the production of the soluble form of VCAM-1 was also stimulated in response to IL-4 or IL-13. Administration of anti-VCAM-1 Ab in vitro blocked tubular morphogenesis induced by IL-4 and IL-13. Angiogenesis induced in vivo in rat cornea by IL-4 and IL-13 was also inhibited by Ab against the rat \u03b14 integrin subunit. These findings suggest that angiogenesis dependent on IL-4 and IL-13 is mainly mediated through a soluble VCAM-1\/\u03b14 integrin pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.165.5.2818","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:58:09Z","timestamp":1398189489000},"page":"2818-2823","source":"Crossref","is-referenced-by-count":110,"title":["The Activity of Soluble VCAM-1 in Angiogenesis Stimulated by IL-4 and IL-13"],"prefix":"10.1093","volume":"165","author":[{"given":"Jun-ichi","family":"Fukushi","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Kyushu University , Maidashi, Higashi-ku, Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Kyushu University , Maidashi, Higashi-ku, Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Kyushu University , Maidashi, Higashi-ku, Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihide","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University , Maidashi, Higashi-ku, Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiko","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Kyushu University , Maidashi, Higashi-ku, Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2026020213065440700_R1","first-page":"27","volume-title":"Nat. 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