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MEC is constitutively expressed by epithelial cells; MEC mRNA is detected in cultured bronchial and mammary gland epithelial cell lines and in epithelia isolated from salivary gland and colon using laser capture microdissection, but not in the endothelial, hemolymphoid, or fibroblastic cell lines tested. Although MEC is poorly expressed in skin, its closest homologue is the keratinocyte-expressed cutaneous T cell-attracting chemokine (CTACK; CCL27), and MEC supports chemotaxis of transfected lymphoid cells expressing CCR10, a known CTACK receptor. In contrast to CTACK, however, MEC also supports migration through CCR3. Consistent with this, MEC attracts eosinophils in addition to memory lymphocyte subsets. These results suggest an important role for MEC in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs.<\/jats:p>","DOI":"10.4049\/jimmunol.165.6.2943","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:30:49Z","timestamp":1398029449000},"page":"2943-2949","source":"Crossref","is-referenced-by-count":273,"title":["Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues"],"prefix":"10.1093","volume":"165","author":[{"given":"Junliang","family":"Pan","sequence":"first","affiliation":[{"name":"Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine , Stanford, CA 94305"},{"name":"Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine , Stanford, CA 94305"},{"name":"Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Gosslar","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine , Stanford, CA 94305"},{"name":"Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine , Stanford, CA 94305"},{"name":"Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Langdon","sequence":"additional","affiliation":[{"name":"Millenium Pharmaceuticals , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Broadwell","sequence":"additional","affiliation":[{"name":"Millenium Pharmaceuticals , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Vierra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Surgery, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C","family":"Genovese","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene C","family":"Butcher","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine , Stanford, CA 94305"},{"name":"Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Soler","sequence":"additional","affiliation":[{"name":"Millenium Pharmaceuticals , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,9,15]]},"reference":[{"key":"2026020213102490900_R1","first-page":"R30","volume-title":"Curr. 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