{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:15:04Z","timestamp":1791245704109,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>EBV is found preferentially in IgD\u2212 B cells in the peripheral blood. This has led to the proposal that the recirculating memory B cell pool is the site of long-lived persistent infection. In this paper we have used CD27, a newly identified specific marker for memory B cells, to test this hypothesis. We show that EBV is tightly restricted in its expression. Less than 1 in 1000 of the infected cells in the peripheral blood are naive (IgD+, CD27\u2212) and &amp;lt;1 in 250 are IgD+ memory cells. Furthermore, EBV was undetectable in the self-renewing peripheral CD5+ or B1 cells, a subset that has not been through a germinal center. No such restriction was observed in tonsillar B cells. Therefore, the virus has access to a range of B cell subsets in the lymph nodes but is tightly restricted to a specific long-lived compartment of B cells, the IgD\u2212, CD27+, and CD5\u2212 memory B cells, in the periphery. We suggest that access to this compartment is essential to allow the growth-promoting latent genes to be switched off to create a site of persistent infection that is neither pathogenic nor a target for immunosurveillance.<\/jats:p>","DOI":"10.4049\/jimmunol.165.6.2975","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:30:49Z","timestamp":1398029449000},"page":"2975-2981","source":"Crossref","is-referenced-by-count":80,"title":["EBV Persistence Involves Strict Selection of Latently Infected B Cells"],"prefix":"10.1093","volume":"165","author":[{"given":"Alexandra M","family":"Joseph","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine , Boston, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J","family":"Babcock","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine , Boston, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Thorley-Lawson","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine , Boston, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,9,15]]},"reference":[{"key":"2026020213120544200_R1","first-page":"2343","volume-title":"Virology","year":"1996"},{"key":"2026020213120544200_R2","first-page":"2397","volume-title":"Virology","year":"1996"},{"key":"2026020213120544200_R3","first-page":"401","volume-title":"Scand. J. Immunol.","year":"1976"},{"key":"2026020213120544200_R4","first-page":"347","volume-title":"J. Virol.","year":"1985"},{"key":"2026020213120544200_R5","first-page":"4510","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1984"},{"key":"2026020213120544200_R6","first-page":"4657","volume-title":"J. Virol.","year":"1997"},{"key":"2026020213120544200_R7","first-page":"1531","volume-title":"J. Virol.","year":"1989"},{"key":"2026020213120544200_R8","first-page":"1755","volume-title":"J. Gen. Virol.","year":"1989"},{"key":"2026020213120544200_R9","first-page":"2846","volume-title":"J. Virol.","year":"1992"},{"key":"2026020213120544200_R10","first-page":"3407","volume-title":"J. Virol.","year":"1990"},{"key":"2026020213120544200_R11","first-page":"415","volume-title":"J. Virol.","year":"1991"},{"key":"2026020213120544200_R12","first-page":"393","volume-title":"Nature","year":"1989"},{"key":"2026020213120544200_R13","first-page":"9150","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2026020213120544200_R14","first-page":"2014","volume-title":"J. Virol.","year":"1993"},{"key":"2026020213120544200_R15","first-page":"593","volume-title":"Cell","year":"1995"},{"key":"2026020213120544200_R16","first-page":"3286","volume-title":"J. Virol.","year":"1996"},{"key":"2026020213120544200_R17","first-page":"4882","volume-title":"J. Virol.","year":"1997"},{"key":"2026020213120544200_R18","first-page":"567","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020213120544200_R19","first-page":"3752","volume-title":"J. Virol.","year":"1995"},{"key":"2026020213120544200_R20","first-page":"3715","volume-title":"J. Virol.","year":"1992"},{"key":"2026020213120544200_R21","first-page":"7374","volume-title":"J. Virol.","year":"1994"},{"key":"2026020213120544200_R22","first-page":"395","volume-title":"Immunity","year":"1998"},{"key":"2026020213120544200_R23","first-page":"158","volume-title":"Epstein-Barr Virus Reports","year":"1999"},{"key":"2026020213120544200_R24","first-page":"1433","volume-title":"Life Sci","year":"1999"},{"key":"2026020213120544200_R25","first-page":"749","volume-title":"Nature","year":"1990"},{"key":"2026020213120544200_R26","first-page":"1","volume-title":"Immunol. Res.","year":"1995"},{"key":"2026020213120544200_R27","first-page":"117","volume-title":"Annu. Rev. Immunol.","year":"1994"},{"key":"2026020213120544200_R28","first-page":"111","volume-title":"Immunol. Rev.","year":"1997"},{"key":"2026020213120544200_R29","first-page":"1691","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020213120544200_R30","first-page":"1679","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020213120544200_R31","first-page":"1288","volume-title":"Blood","year":"1997"},{"key":"2026020213120544200_R32","first-page":"389","volume-title":"Immunol. Today","year":"1991"},{"key":"2026020213120544200_R33","first-page":"312","volume-title":"Immunol. Today","year":"1999"},{"key":"2026020213120544200_R34","first-page":"173","volume-title":"Immunity","year":"1996"},{"key":"2026020213120544200_R35","first-page":"50","volume-title":"Int. J. Cancer","year":"1999"},{"key":"2026020213120544200_R36","first-page":"289","volume-title":"Adv. Exp. Med. Biol.","year":"1994"},{"key":"2026020213120544200_R37","first-page":"857","volume-title":"Int. J. Cancer","year":"1968"},{"key":"2026020213120544200_R38","first-page":"53","volume-title":"Immunol. Rev.","year":"1997"},{"key":"2026020213120544200_R39","first-page":"141","volume-title":"Immunol. Today","year":"1999"},{"key":"2026020213120544200_R40","first-page":"267","volume-title":"Immunol. Today","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/6\/2975\/62134935\/2975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/6\/2975\/62134935\/2975.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:19:33Z","timestamp":1770056373000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/165\/6\/2975\/8038912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2000,9,15]]},"published-print":{"date-parts":[[2000,9,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.165.6.2975","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,9]]},"published":{"date-parts":[[2000,9]]}}}