{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:55:23Z","timestamp":1791050123351,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic Th2-dominated inflammation and exaggerated IL-6 production are characteristic features of the asthmatic airway. To understand the processes that are responsible for the chronicity of this response and the role(s) of IL-6 in the regulation of airway Th2 inflammation, we compared the responses induced by OVA in sensitized wild-type mice, IL-6 deficient (\u2212\/\u2212) mice, and transgenic mice in which IL-6 was overexpressed in the airway (CC10-IL-6 mice). When compared with wild-type mice, IL-6\u2212\/\u2212 mice manifest exaggerated inflammation and eosinophilia, increased levels of IL-4, IL-5, and IL-13 protein and mRNA, exaggerated levels of eotaxin, JE\/monocyte chemoattractant protein-1, macrophage inflammatory protein-1\u03b1 and -2, and mRNA, increased bronchoalveolar lavage (BAL) TGF-\u03b21, and exaggerated airway responses to aerosolized methacholine. In contrast, CC10-IL-6 mice, on both C57BL\/6 and BALB\/c backgrounds, manifest diminished inflammation and eosinophilia, decreased levels of IL-4, IL-5, and IL-13 protein and mRNA, and decreased levels of bronchoalveolar lavage TGF-\u03b21. IL-6 also decreased the expression of endothelial VCAM-1 and airway responsiveness to methacholine in these animals. These alterations in the IL-6\u2212\/\u2212 and CC10-IL-6 mice were not associated with significant decreases or increases in the levels of IFN-\u03b3, respectively. These studies demonstrate that endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation and that this inhibition is not mediated by regulatory effects of IFN-\u03b3. IL-6 may be an important anti-inflammatory, counterregulatory, and healing cytokine in the airway.<\/jats:p>","DOI":"10.4049\/jimmunol.165.7.4051","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:25:30Z","timestamp":1398047130000},"page":"4051-4061","source":"Crossref","is-referenced-by-count":86,"title":["Endogenous and Exogenous IL-6 Inhibit Aeroallergen-Induced Th2 Inflammation"],"prefix":"10.1093","volume":"165","author":[{"given":"Jingming","family":"Wang","sequence":"first","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Homer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT 06520"},{"name":"Pathology and Laboratory Medicine Service, Veterans Administration-Connecticut Health Care System , West Haven, CT 06516"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A","family":"Elias","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,10,1]]},"reference":[{"key":"2025032908050487800_R1","first-page":"735","volume-title":"Fishman\u2019s Pulmonary Diseases and Disorders","year":"1998"},{"key":"2025032908050487800_R2","first-page":"862","volume-title":"N. Eng. J. Med.","year":"1992"},{"key":"2025032908050487800_R3","first-page":"313","volume-title":"J. Allergy Clin. Immunol.","year":"1993"},{"key":"2025032908050487800_R4","first-page":"29","volume-title":"Airway Wall Remodelling in Asthma","year":"1997"},{"key":"2025032908050487800_R5","first-page":"1001","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2025032908050487800_R6","first-page":"999","volume-title":"Eur. Resp. Rev.","year":"1998"},{"key":"2025032908050487800_R7","first-page":"1016","volume-title":"Eur. Resp. Rev.","year":"1998"},{"key":"2025032908050487800_R8","first-page":"229","volume-title":"Lung Biology in Health and Disease","year":"1993"},{"key":"2025032908050487800_R9","first-page":"421","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2025032908050487800_R10","first-page":"S27","volume-title":"J. Allergy Clin. Immunol.","year":"1996"},{"key":"2025032908050487800_R11","first-page":"5094","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032908050487800_R12","first-page":"193","volume-title":"Am. J. Pathol.","year":"1997"},{"key":"2025032908050487800_R13","first-page":"1345","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032908050487800_R14","first-page":"73","volume-title":"Int. Arch. Allergy Immunol.","year":"1996"},{"key":"2025032908050487800_R15","first-page":"471","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"1994"},{"key":"2025032908050487800_R16","first-page":"958","volume-title":"J. Allergy Clin. Immunol.","year":"1992"},{"key":"2025032908050487800_R17","first-page":"561","volume-title":"Science","year":"1994"},{"key":"2025032908050487800_R18","first-page":"1243","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2025032908050487800_R19","first-page":"1512","volume-title":"J. Infect. Dis.","year":"1998"},{"key":"2025032908050487800_R20","first-page":"2622","volume-title":"J. Immunol.","year":"1992"},{"key":"2025032908050487800_R21","first-page":"8222","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1998"},{"key":"2025032908050487800_R22","first-page":"4843","volume-title":"Infect. Immun.","year":"1997"},{"key":"2025032908050487800_R23","first-page":"339","volume-title":"Nature","year":"1994"},{"key":"2025032908050487800_R24","first-page":"311","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2025032908050487800_R25","first-page":"1097","volume-title":"Am. J. Pathol.","year":"1991"},{"key":"2025032908050487800_R26","first-page":"439","volume-title":"J. Infect. Dis.","year":"1997"},{"key":"2025032908050487800_R27","first-page":"714","volume-title":"Infect. Immun.","year":"1996"},{"key":"2025032908050487800_R28","first-page":"239","volume-title":"Brain Res.","year":"1996"},{"key":"2025032908050487800_R29","first-page":"300","volume-title":"Cytokine","year":"1997"},{"key":"2025032908050487800_R30","first-page":"461","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032908050487800_R31","first-page":"2028","volume-title":"J. Clin. Invest.","year":"1994"},{"key":"2025032908050487800_R32","first-page":"289","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2000"},{"key":"2025032908050487800_R33","first-page":"1739","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032908050487800_R34","first-page":"1970","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2025032908050487800_R35","first-page":"1737","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032908050487800_R36","first-page":"779","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2025032908050487800_R37","first-page":"766","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1997"},{"key":"2025032908050487800_R38","first-page":"138","volume-title":"Immunol. Today","year":"1996"},{"key":"2025032908050487800_R39","first-page":"6","volume-title":"J. Appl. 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Med.","year":"1998"},{"key":"2025032908050487800_R50","first-page":"334","volume-title":"Mol. Med.","year":"1996"},{"key":"2025032908050487800_R51","first-page":"1064","volume-title":"J. Clin. Invest.","year":"1997"},{"key":"2025032908050487800_R52","first-page":"777","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"1999"},{"key":"2025032908050487800_R53","first-page":"107","volume-title":"New Engl. J. Med.","year":"1995"},{"key":"2025032908050487800_R54","first-page":"3437","volume-title":"J. Immunol.","year":"1991"},{"key":"2025032908050487800_R55","first-page":"23013","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2025032908050487800_R56","first-page":"984","volume-title":"Arterioscler. Thromb. Vasc. Biol.","year":"1998"},{"key":"2025032908050487800_R57","first-page":"224","volume-title":"Eur. J. Ophthalmol.","year":"1998"},{"key":"2025032908050487800_R58","first-page":"382","volume-title":"Biochem. Biophys. Res. 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