{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:52:50Z","timestamp":1783975970319,"version":"3.55.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Homing of effector T cells to sites of inflammation, particularly in the skin, is dependent on T cell expression of ligands for the endothelial selectins. Underlying expression of these ligands is the expression of \u03b1(1,3)-fucosyltransferase VII (FucT-VII), a FucT essential for biosynthesis of selectin ligands. FucT-VII is sharply induced in activated T cells by IL-12, but cytokines other than IL-12 that induce FucT-VII and functional selectin ligands have not been identified, and are likely to be important in homing of T cells to other selectin-dependent sites. Screening of a number of cytokines known to be active on T cells identified only TGF-\u03b21 as able to up-regulate FucT-VII mRNA levels and selectin ligands on activated CD4 T cells. The sharp increase in FucT-VII induced by TGF-\u03b21 in activated T cells was completely blocked by pharmacologic inhibition of p38 mitogen-activated protein kinase, but was unaffected by mitogen-activated protein\/extracellular signal-related kinase kinase inhibitors. The selective ability of TGF-\u03b21 to induce selectin ligands on activated T cells is likely important for T cell homing to the gut, which is a strongly selectin-dependent site, and correlates with the ability of TGF-\u03b21 to coordinately induce other gut-associated homing pathways.<\/jats:p>","DOI":"10.4049\/jimmunol.165.9.5011","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:59:08Z","timestamp":1398034748000},"page":"5011-5016","source":"Crossref","is-referenced-by-count":50,"title":["Potent Induction of \u03b1(1,3)-Fucosyltransferase VII in Activated CD4+ T Cells by TGF-\u03b21 Through a p38 Mitogen-Activated Protein Kinase-Dependent Pathway"],"prefix":"10.1093","volume":"165","author":[{"given":"Amy J","family":"Wagers","sequence":"first","affiliation":[{"name":"Department of Microbiology-Immunology, Northwestern University Medical School , Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey S","family":"Kansas","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Northwestern University Medical School , Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2026020213111750000_R1","first-page":"3259","volume-title":"Blood","year":"1996"},{"key":"2026020213111750000_R2","first-page":"1033","volume-title":"Cell","year":"1991"},{"key":"2026020213111750000_R3","first-page":"81","volume-title":"Nature","year":"1997"},{"key":"2026020213111750000_R4","first-page":"563","volume-title":"Cell","year":"1996"},{"key":"2026020213111750000_R5","first-page":"2782","volume-title":"J. Clin. Invest.","year":"1997"},{"key":"2026020213111750000_R6","first-page":"4459","volume-title":"Blood","year":"1997"},{"key":"2026020213111750000_R7","first-page":"2225","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020213111750000_R8","first-page":"3193","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213111750000_R9","first-page":"643","volume-title":"Cell","year":"1996"},{"key":"2026020213111750000_R10","first-page":"911","volume-title":"J. Cell Biol.","year":"1996"},{"key":"2026020213111750000_R11","first-page":"1214","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213111750000_R12","first-page":"1924","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1992"},{"key":"2026020213111750000_R13","first-page":"190","volume-title":"Nature","year":"1994"},{"key":"2026020213111750000_R14","first-page":"1917","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020213111750000_R15","first-page":"881","volume-title":"Immunity","year":"1998"},{"key":"2026020213111750000_R16","first-page":"4781","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020213111750000_R17","first-page":"571","volume-title":"Immunity","year":"1997"},{"key":"2026020213111750000_R18","first-page":"423","volume-title":"Immunity","year":"1998"},{"key":"2026020213111750000_R19","first-page":"3899","volume-title":"EMBO J.","year":"1993"},{"key":"2026020213111750000_R20","first-page":"458","volume-title":"Curr. Opin. Immunol.","year":"1994"},{"key":"2026020213111750000_R21","first-page":"1448","volume-title":"Blood","year":"1999"},{"key":"2026020213111750000_R22","first-page":"737","volume-title":"Cell","year":"1998"},{"key":"2026020213111750000_R23","first-page":"1345","volume-title":"EMBO J.","year":"1999"},{"key":"2026020213111750000_R24","first-page":"389","volume-title":"Pharmacol. Ther.","year":"1999"},{"key":"2026020213111750000_R25","first-page":"4246","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213111750000_R26","first-page":"27161","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020213111750000_R27","first-page":"3746","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213111750000_R28","first-page":"573","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020213111750000_R29","first-page":"2159","volume-title":"Science","year":"1999"},{"key":"2026020213111750000_R30","first-page":"14470","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1999"},{"key":"2026020213111750000_R31","first-page":"776","volume-title":"Nature","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/9\/5011\/62733962\/5011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/9\/5011\/62733962\/5011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:18:03Z","timestamp":1770056283000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/165\/9\/5011\/8038801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11,1]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2000,11,1]]},"published-print":{"date-parts":[[2000,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.165.9.5011","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,11]]},"published":{"date-parts":[[2000,11,1]]}}}