{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:20:44Z","timestamp":1790868044241,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infection of B6 mice with the intracellular pathogen Listeria monocytogenes (LM) results in the activation of CD8+ T cells that respond to Ag presented by both MHC class Ia and class Ib molecules. Enzyme-linked immunospot analysis reveals that these CTL populations expand and contract at different times following a primary sublethal LM infection. Between days 4 and 6 postinfection, class Ib-restricted CTL exhibit a rapid proliferative response that is primarily H2-M3 restricted. The peak response of class Ia-restricted CD8+ T cells occurs a few days later, after the majority of bacteria have been cleared. Although class Ia-restricted CTL exhibit a vigorous recall response to secondary LM infection, we observe limited expansion of class Ib-restricted memory CTL, even in MHC class Ia-deficient mice (B6.Kb\u2212\/\u2212Db\u2212\/\u2212). Despite this lack of enhanced expansion in vivo, class Ib-restricted memory CTL retain the ability to proliferate and expand when provided with Ag in vitro. Furthermore, we demonstrate that in vivo depletion of CD8+ T cells in LM-immune B6.Kb\u2212\/\u2212Db\u2212\/\u2212 mice severely impairs memory protection. Together, these data demonstrate that class Ib-restricted CTL play an important role in clearing a primary LM infection and generate a memory population capable of providing significant protection against subsequent infection.<\/jats:p>","DOI":"10.4049\/jimmunol.165.9.5192","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:59:08Z","timestamp":1398034748000},"page":"5192-5201","source":"Crossref","is-referenced-by-count":55,"title":["MHC Class Ib-Restricted CTL Provide Protection Against Primary and Secondary\n                    <i>Listeria monocytogenes<\/i>\n                    Infection"],"prefix":"10.1093","volume":"165","author":[{"given":"Michael S","family":"Seaman","sequence":"first","affiliation":[{"name":"Immunology Graduate Program, University of Chicago , Chicago IL 60637"},{"name":"Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235; and Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, University of Chicago , Chicago IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyung-Ru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Forman","sequence":"additional","affiliation":[{"name":"Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235; and Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, University of Chicago , Chicago IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2026020213125713600_R1","first-page":"152","volume-title":"Immunologist.","year":"1995"},{"key":"2026020213125713600_R2","first-page":"5090","volume-title":"Infect. 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