{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:48:09Z","timestamp":1789901289066,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>51p1 is an allele of VH1-69 that frequently is expressed by chronic lymphocytic leukemia (CLL) B cells with little or no somatic mutation. The rearranged 51p1 genes expressed by CLL B cells have a distinctive use of D segments D3-3\/DXP4 and D3-10\/DXP\u20321, a favored use of JH6, and a longer third complementarity-determining region than the rearranged Ig genes used by CLL B cells that express VH1 genes other than VH1-69. We examined the 51p1-encoded Ig expressed by blood B cells of healthy donors. In contrast to the infrequent use of JH4 by 51p1-expressing CLL (e.g., 4%), 36% of the rearranged 51p1 sequences from normal blood B cells used JH4. Furthermore, the D segment use of the rearranged 51p1 sequences from normal blood B cells was not restricted, but reflected the D segment use of nonselected IgH of normal B cells. Finally, the mean length of the third complementarity-determining region for the 51p1 genes of normal blood B cells was 14.6 \u00b1 4.3 (SD) codons. This is significantly shorter than that noted for 51p1-expressing CLL B cells (18.8 \u00b1 3.2; p &amp;lt; 0.0001, n = 51). This study demonstrates that the 51p1-encoded IgH expressed in CLL are not representative of the 51p1-encoded IgH expressed by normal blood B cells, indicating that CLL B cells express IgH that are distinctive from those found in the normal adult blood B cell repertoire.<\/jats:p>","DOI":"10.4049\/jimmunol.166.1.95","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:32:59Z","timestamp":1398043979000},"page":"95-102","source":"Crossref","is-referenced-by-count":59,"title":["Normal B Cells Express <i>51p1<\/i>-Encoded Ig Heavy Chains That Are Distinct From Those Expressed by Chronic Lymphocytic Leukemia B Cells"],"prefix":"10.1093","volume":"166","author":[{"suffix":"II","given":"George F","family":"Widhopf","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Kipps","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"2025032713361296100_R1"},{"key":"2025032713361296100_R2","first-page":"399","volume-title":"J. 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