{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:51:16Z","timestamp":1791154276158,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Both IgG and IgA Abs have been implicated in host defense against bacterial infections, although their relative contributions remain unclear. We generated a unique panel of human chimeric Abs of all human IgG and IgA subclasses with identical V genes against porin A, a major subcapsular protein Ag of Neisseria meningitidis and a vaccine candidate. Chimeric Abs were produced in baby hamster kidney cells, and IgA-producing clones were cotransfected with human J chain and\/or human secretory component. Although IgG (isotypes IgG1\u20133) mediated efficient complement-dependent lysis, IgA was unable to. However, IgA proved equally active to IgG in stimulating polymorphonuclear leukocyte respiratory burst. Remarkably, although porin-specific monomeric, dimeric, and polymeric IgA triggered efficient phagocytosis, secretory IgA did not. These studies reveal unique and nonoverlapping roles for IgG and IgA Abs in defense against meningococcal infections.<\/jats:p>","DOI":"10.4049\/jimmunol.166.10.6250","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:28:25Z","timestamp":1398032905000},"page":"6250-6256","source":"Crossref","is-referenced-by-count":112,"title":["Activity of Human IgG and IgA Subclasses in Immune Defense Against\n                    <i>Neisseria meningitidis<\/i>\n                    Serogroup B"],"prefix":"10.1093","volume":"166","author":[{"given":"Gestur","family":"Vidarsson","sequence":"first","affiliation":[{"name":"Department of Immunology, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W-Ludo","family":"van der Pol","sequence":"additional","affiliation":[{"name":"Department of Immunology, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M H","family":"van den Elsen","sequence":"additional","affiliation":[{"name":"Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrie\u0308tte","family":"Vile\u0301","sequence":"additional","affiliation":[{"name":"Department of Immunology, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Medarex Europe, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Duijs","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Craig","family":"Morton","sequence":"additional","affiliation":[{"name":"Laboratory of Immunohistochemistry and Immunopathology (LIIPAT), The National Hospital, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Boel","sequence":"additional","affiliation":[{"name":"Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R","family":"Daha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise","family":"Corthe\u0301sy","sequence":"additional","affiliation":[{"name":"Division d\u2019Immunologie et d\u2019Allergie, Centre Hospitalier Universitaire Vaudois , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G J","family":"van de Winkel","sequence":"additional","affiliation":[{"name":"Department of Immunology, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Genmab, Infectious Diseases and Inflammation, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,5,15]]},"reference":[{"key":"2026020209184693900_R1","first-page":"1307","volume-title":"J. Exp. Med.","year":"1969"},{"key":"2026020209184693900_R2","first-page":"1327","volume-title":"J. Exp. Med.","year":"1969"},{"key":"2026020209184693900_R3","first-page":"91","volume-title":"Pediatrics","year":"1985"},{"key":"2026020209184693900_R4","first-page":"1710","volume-title":"Infect. Immun.","year":"1997"},{"key":"2026020209184693900_R5","first-page":"1093","volume-title":"Lancet","year":"1991"},{"key":"2026020209184693900_R6","first-page":"355","volume-title":"Lancet","year":"1983"},{"key":"2026020209184693900_R7","first-page":"1334","volume-title":"Vaccine","year":"2000"},{"key":"2026020209184693900_R8","first-page":"121","volume-title":"Curr. Opin. Immunol.","year":"1997"},{"key":"2026020209184693900_R9","first-page":"271","volume-title":"Curr. Opin. Infect. Dis.","year":"1998"},{"key":"2026020209184693900_R10","first-page":"423","volume-title":"Crit. Rev. Immunol.","year":"1996"},{"key":"2026020209184693900_R11","first-page":"848","volume-title":"J. Infect. Dis.","year":"1994"},{"key":"2026020209184693900_R12","first-page":"581","volume-title":"Scand. J. Immunol.","year":"1994"},{"key":"2026020209184693900_R13","first-page":"1266","volume-title":"J. Infect. Dis.","year":"1987"},{"key":"2026020209184693900_R14","first-page":"1779","volume-title":"J. Immunol.","year":"1975"},{"key":"2026020209184693900_R15","first-page":"452","volume-title":"J. Exp. Med.","year":"1980"},{"key":"2026020209184693900_R16","first-page":"2552","volume-title":"Infect. Immun.","year":"1999"},{"key":"2026020209184693900_R17","first-page":"1495","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020209184693900_R18","first-page":"113","volume-title":"Proteins","year":"1997"},{"key":"2026020209184693900_R19","first-page":"245","volume-title":"J. Immunol. Methods","year":"2001"},{"key":"2026020209184693900_R20","first-page":"153","volume-title":"J. Immunol. Methods","year":"2000"},{"key":"2026020209184693900_R21","first-page":"375","volume-title":"Eur. J. Immunol.","year":"1987"},{"key":"2026020209184693900_R22","first-page":"276","volume-title":"Nat. Biotechnol.","year":"1999"},{"key":"2026020209184693900_R23","first-page":"3029","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1999"},{"key":"2026020209184693900_R24","first-page":"349","volume-title":"Biochem. J.","year":"1991"},{"key":"2026020209184693900_R25","first-page":"173","volume-title":"J. Immunol. Methods","year":"1987"},{"key":"2026020209184693900_R26","first-page":"222","volume-title":"Immunogenetics","year":"1998"},{"key":"2026020209184693900_R27","first-page":"1531","volume-title":"J. Infect. Dis.","year":"1997"},{"key":"2026020209184693900_R28","first-page":"6364","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1997"},{"key":"2026020209184693900_R29","first-page":"423","volume-title":"J. Infect. Dis.","year":"1999"},{"key":"2026020209184693900_R30","first-page":"1251","volume-title":"Biol. Chem.","year":"1999"},{"key":"2026020209184693900_R31","first-page":"1351","volume-title":"J. Exp. Med.","year":"1987"},{"key":"2026020209184693900_R32","first-page":"321","volume-title":"Eur. J. Immunol.","year":"1987"},{"key":"2026020209184693900_R33","first-page":"1","volume-title":"Adv. Immunol.","year":"1992"},{"key":"2026020209184693900_R34","first-page":"4900","volume-title":"Infect. Immun.","year":"1995"},{"key":"2026020209184693900_R35","first-page":"79","volume-title":"Human IgG Fc Receptors","year":"1996"},{"key":"2026020209184693900_R36","first-page":"5","volume-title":"Human IgG Fc Receptors","year":"1996"},{"key":"2026020209184693900_R37","first-page":"491","volume-title":"Immunology","year":"1991"},{"key":"2026020209184693900_R38","first-page":"1579","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209184693900_R39","first-page":"23508","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020209184693900_R40","first-page":"31456","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020209184693900_R41","first-page":"680","volume-title":"Nat. Med.","year":"2000"},{"key":"2026020209184693900_R42","first-page":"1103","volume-title":"Science","year":"1975"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/166\/10\/6250\/62532877\/6250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/166\/10\/6250\/62532877\/6250.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:26:10Z","timestamp":1770042370000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/166\/10\/6250\/8027095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2001,5,15]]},"published-print":{"date-parts":[[2001,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.166.10.6250","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,5]]},"published":{"date-parts":[[2001,5]]}}}