{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:31:21Z","timestamp":1770085881506,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To understand the mechanisms that promote recruitment and survival of T cells within the pediatric inflamed joint, we have studied the expression of CCR4 and CCR5 on synovial fluid T cells and matched peripheral blood samples from juvenile rheumatoid arthritis (JRA) patients using three-color flow cytometric analysis. Thymus- and activation-regulated chemokine and macrophage-derived chemokine, ligands for CCR4, were measured by ELISA in JRA synovial fluid, JRA plasma, adult rheumatoid arthritis synovial fluid, and normal plasma. IL-4 and IFN-\u03b3 mRNA production was assessed in CD4+\/CCR4+ and CD4+\/CCR4\u2212 cell subsets. We found accumulations of both CCR4+ and CCR5+ T cells in JRA synovial fluids and a correlation for increased numbers of CCR4+ T cells in samples collected early in the disease process. Thymus- and activation-regulated chemokine was detected in JRA synovial fluid and plasma samples, but not in adult rheumatoid arthritis synovial fluid or control plasma. Macrophage-derived chemokine was present in all samples. CD4+\/CCR4+ synovial lymphocytes produced more IL-4 and less IFN-\u03b3 than CD4+\/CCR4\u2212 cells. These findings suggest that CCR4+ T cells in the JRA joint may function early in disease in an anti-inflammatory capacity through the production of type 2 cytokines and may play a role in determining disease phenotype.<\/jats:p>","DOI":"10.4049\/jimmunol.166.11.6899","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:28Z","timestamp":1398034528000},"page":"6899-6906","source":"Crossref","is-referenced-by-count":40,"title":["Chemokine Receptor CCR4 on CD4+ T Cells in Juvenile Rheumatoid Arthritis Synovial Fluid Defines a Subset of Cells with Increased IL-4:IFN-\u03b3 mRNA Ratios"],"prefix":"10.1093","volume":"166","author":[{"given":"Susan D","family":"Thompson","sequence":"first","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorie K","family":"Luyrink","sequence":"additional","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T Brent","family":"Graham","sequence":"additional","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Tsoras","sequence":"additional","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Ryan","sequence":"additional","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray H","family":"Passo","sequence":"additional","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N","family":"Glass","sequence":"additional","affiliation":[{"name":"William S. Rowe Division of Rheumatology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"2026020209181284500_R1","first-page":"1356","volume-title":"J. Rheumatol.","year":"1995"},{"key":"2026020209181284500_R2","first-page":"227","volume-title":"Annu. Rev. Immunol.","year":"1994"},{"key":"2026020209181284500_R3","first-page":"397","volume-title":"Annu. Rev. 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