{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:37:30Z","timestamp":1791862650015,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mice deficient in CD18, which lack all four CD11 integrins, have leukocytosis and increased susceptibility to bacterial infection. To determine the effect of deficiencies in LFA-1 (CD11a\/CD18) or Mac-1 (CD11b\/CD18) on host defense against systemic bacterial infection, knockout mice were inoculated i.p. with Streptococcus pneumoniae. Increased mortality occurred in both LFA-1\u2212\/\u2212 (15 of 17 vs 13 of 35 in wild type (WT), p &amp;lt; 0.01) and Mac-1\u2212\/\u2212 (17 of 34 vs 6 of 25, p &amp;lt; 0.01) mice. All deaths in LFA-1\u2212\/\u2212 mice occurred after 72 h, whereas most deaths in Mac-1\u2212\/\u2212 mice occurred within 24\u201348 h. At 24 h, 21 of 27 Mac-1\u2212\/\u2212 mice were bacteremic, vs 15 of 25 WT (p = 0.05); no difference was observed between LFA-1\u2212\/\u2212 and WT. Increased bacteria were recovered from Mac-1\u2212\/\u2212 spleens at 2 h (p = 0.03) and 6 h (p = 0.002) and from livers (p = 0.001) by 6 h. No difference was observed at 2 h in LFA-1\u2212\/\u2212 mice, but by 6 h increased bacteria were recovered from spleens (p = 0.008) and livers (p = 0.04). Baseline and peak leukocyte counts were similar between Mac-1\u2212\/\u2212 and WT, but elevated in LFA-1\u2212\/\u2212. At 8 h, peritoneal neutrophils were increased in Mac-1\u2212\/\u2212, but not significantly different in LFA-1\u2212\/\u2212. Histopathologically, at 24 h Mac-1\u2212\/\u2212 animals had bacteremia and lymphoid depletion, consistent with sepsis. LFA-1\u2212\/\u2212 mice had increased incidence of otitis media and meningitis\/encephalitis vs WT at 72 and 96 h. Both Mac-1 and LFA-1 play important but distinct roles in host defense to S. pneumoniae.<\/jats:p>","DOI":"10.4049\/jimmunol.166.12.7362","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:36:18Z","timestamp":1398036978000},"page":"7362-7369","source":"Crossref","is-referenced-by-count":63,"title":["The Differential Roles of LFA-1 and Mac-1 in Host Defense Against Systemic Infection with <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1093","volume":"166","author":[{"given":"Joseph E","family":"Prince","sequence":"first","affiliation":[{"name":"Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory F","family":"Brayton","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milligan C","family":"Fossett","sequence":"additional","affiliation":[{"name":"Speros P. Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Durand","sequence":"additional","affiliation":[{"name":"Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon L","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Wayne","family":"Smith","sequence":"additional","affiliation":[{"name":"Speros P. Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine , Houston, TX 77030"},{"name":"Speros P. Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,6,15]]},"reference":[{"key":"2025032907393707500_R1","first-page":"3955","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","year":"1995"},{"key":"2025032907393707500_R2","first-page":"8667","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1985"},{"key":"2025032907393707500_R3","first-page":"15","volume-title":"J. 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