{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:26:28Z","timestamp":1770085588897,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>H2-M3-restricted presentation of N-formyl methionine (f-Met) peptides to CD8+ T cells provides a mechanism for selective recognition of bacterial infection. In this report we demonstrate that Listeria monocytogenes infection induces distinct CD8+ T cell populations specific for each of the known Listeria-derived formyl methionine peptides presented by M3. The sum H2-M3-restricted, Listeria-specific T cell response constitutes a major fraction of the total CD8+ T cell response to primary infection. H2-M3-restricted T cell populations expand synchronously in vivo and achieve peak frequencies \u223c2 days earlier than MHC class Ia-restricted T cell populations. Although cross-recognition of different f-Met peptides by M3-restricted T cells was previously described, costaining of CD8+ T cells ex vivo with H2-M3 tetramers complexed with different f-Met peptides shows that the majority of Listeria-specific, M3-restricted CD8+ T cells are peptide specific. In contrast to the highly predictable size and immunodominance hierarchies of MHC class Ia-restricted T cell responses, the magnitudes of T cell responses specific for H2-M3-restricted peptides are remarkably variable between genetically identical mice. Our findings demonstrate that H2-M3-restricted T cell responses are distinct from classically restricted T cell responses to bacterial infection.<\/jats:p>","DOI":"10.4049\/jimmunol.166.2.1132","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:56:47Z","timestamp":1398034607000},"page":"1132-1140","source":"Crossref","is-referenced-by-count":16,"title":["Variable Immunodominance Hierarchies for H2-M3-Restricted\n                    <i>N<\/i>\n                    -Formyl Peptides Following Bacterial Infection"],"prefix":"10.1093","volume":"166","author":[{"given":"Kristen M","family":"Kerksiek","sequence":"first","affiliation":[{"name":"Sections of Infectious Diseases and Immunobiology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk H","family":"Busch","sequence":"additional","affiliation":[{"name":"Sections of Infectious Diseases and Immunobiology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric G","family":"Pamer","sequence":"additional","affiliation":[{"name":"Sections of Infectious Diseases and Immunobiology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,1,15]]},"reference":[{"key":"2026020208112555300_R1","first-page":"593","volume-title":"Annu. 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