{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:47:17Z","timestamp":1791294437532,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A previously unreported CD8+CD28+CD11b+ T cell subset occurs in healthy individuals and expands in patients suffering from primary viral infections. In functional terms, these cells share the features of naive\/memory CD8+CD28+CD11b\u2212 and terminally differentiated effector CD8+CD28\u2212CD11b+ subpopulations. Like CD28\u2212 cells, CD28+CD11b+ lymphocytes have the ability to produce IFN-\u03b3, to express perforin granules in vivo, and to exert a potent cytolytic activity. Moreover, these cells can respond to chemotactic stimuli and can efficiently cross the endothelial barrier. In contrast, like their CD11b\u2212 counterpart, they still produce IL-2 and retain the ability to proliferate following mitogenic stimuli. The same CD28+CD11b+ subpopulation detected in vivo could be generated by culturing naive CD28+CD11b\u2212 cells in the presence of mitogenic stimuli following the acquisition of a CD45RO+ memory phenotype. Considering both phenotypic and functional properties, we argue that this subset may therefore constitute an intermediate phenotype in the process of CD8+ T cell differentiation and that the CD11b marker expression can distinguish between memory- and effector-type T cells in the human CD8+CD28+ T cell subset.<\/jats:p>","DOI":"10.4049\/jimmunol.166.2.900","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:56:47Z","timestamp":1398034607000},"page":"900-907","source":"Crossref","is-referenced-by-count":42,"title":["CD11b Expression Identifies CD8+CD28+ T Lymphocytes with Phenotype and Function of Both Naive\/Memory and Effector Cells"],"prefix":"10.1093","volume":"166","author":[{"given":"Simona","family":"Fiorentini","sequence":"first","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Licenziati","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Alessandri","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Castelli","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Caligaris","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bonafede","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Grassi","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emirena","family":"Garrafa","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Balsari","sequence":"additional","affiliation":[{"name":"Chair of Immunology, National Cancer Institute, University of Milan , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Turano","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Caruso","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and, University of Brescia Medical School , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,1,15]]},"reference":[{"key":"2026020208074964900_R1","first-page":"465","volume-title":"Clin. 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