{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:56:48Z","timestamp":1761155808433,"version":"3.40.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infection of mice with a series of heterologous viruses causes a reduction of memory CD8+ T cells specific to viruses from earlier infections, but the fate of the virus-specific memory CD4+ T cell pool following multiple virus infections has been unknown. We have previously reported that the virus-specific CD4+ Th precursor (Thp) frequency remains stable into long-term immunity following lymphocytic choriomeningitis virus (LCMV) infection. In this study, we questioned whether heterologous virus infections or injection with soluble protein CD4 Ags would impact this stable LCMV-specific CD4+ Thp memory pool. Limiting dilution analyses for IL-2-producing cells and intracellular cytokine staining for IFN-\u03b3 revealed that the LCMV-specific CD4+ Thp frequency remains relatively stable following multiple heterologous virus infections or protein Ag immunizations, even under conditions that dramatically reduce the LCMV-specific CD8+ CTL precursor frequency. These data indicate that the CD4+ and CD8+ memory T cell pools are regulated independently and that the loss in CD8+ T cell memory following heterologous virus infections is not a consequence of a parallel loss in the memory CD4+ T cell population.<\/jats:p>","DOI":"10.4049\/jimmunol.166.3.1554","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:55:06Z","timestamp":1398045306000},"page":"1554-1561","source":"Crossref","is-referenced-by-count":43,"title":["Independent Regulation of Lymphocytic Choriomeningitis Virus-Specific T Cell Memory Pools: Relative Stability of CD4 Memory Under Conditions of CD8 Memory T Cell Loss"],"prefix":"10.1093","volume":"166","author":[{"given":"Steven M","family":"Varga","sequence":"first","affiliation":[{"name":"Program in Immunology and Virology, University of Massachusetts Medical Center , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa K","family":"Selin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical Center , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical Center , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"first-page":"2165","volume-title":"J. 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