{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:34:14Z","timestamp":1790703254301,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have begun to dissect the cellular requirements for generation of immunity against enteric infection by Listeria monocytogenes using a novel T\u2212 B\u2212 NK\u2212 mouse strain (mice double deficient for the common cytokine receptor \u03b3-chain (\u03b3c) and the recombinase-activating gene-2 (RAG2\/\u03b3c mice). Initial experiments showed that C57BL\/6 mice and alymphoid RAG2\/\u03b3c mice had similar kinetics of bacterial accumulation in the spleen, liver, and brain early after intragastric L. monocytogenes infection (up to day 3), calling into question the physiologic role of gut-associated lymphoid cells during the passage of this enterobacterium into the host. However, in contrast to C57BL\/6 mice, RAG2\/\u03b3c mice rapidly succumbed to disseminated infection by day 7. Polyclonal lymph node CD4+ and CD8+ \u03b1\u03b2 T cells were able to confer RAG2\/\u03b3c mice with long-lasting protection against enteric L. monocytogenes infection in the absence of \u03b3\u03b4 T, NK, and NK-T cells. Moreover, these \u03b1\u03b2 T-reconstituted RAG2\/\u03b3c mice produced IFN-\u03b3 at levels comparable to C57BL\/6 mice in response to L. monocytogenes both in vitro and in vivo. Protection was IFN-\u03b3 dependent, as RAG2\/\u03b3c mice reconstituted with IFN-\u03b3-deficient \u03b1\u03b2 T cells were unable to control enteric L. monocytogenes infection. Furthermore, \u03b1\u03b2 T cell-reconstituted RAG2\/\u03b3c mice were able to mount memory responses when challenged with lethal doses of L. monocytogenes. These data suggest that NK, NK-T, \u03b3\u03b4 T, and B cells are functionally redundant in the immunity against oral L. monocytogenes infection, and that in their absence \u03b1\u03b2 T cells are able to mediate the early IFN-\u03b3 production required for both innate and adaptive immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.166.3.1871","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:55:06Z","timestamp":1398030906000},"page":"1871-1876","source":"Crossref","is-referenced-by-count":26,"title":["Conventional \u03b1\u03b2 T Cells Are Sufficient for Innate and Adaptive Immunity Against Enteric\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"166","author":[{"given":"S\u00f8ren","family":"Bregenholt","sequence":"first","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoi\u0308de, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Berche","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 411, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Brombacher","sequence":"additional","affiliation":[{"name":"University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoi\u0308de, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"key":"2026020209131005600_R1","first-page":"245","volume-title":"Microbiol. 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