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To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.<\/jats:p>","DOI":"10.4049\/jimmunol.166.3.2055","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:55:06Z","timestamp":1398030906000},"page":"2055-2062","source":"Crossref","is-referenced-by-count":197,"title":["Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice"],"prefix":"10.1093","volume":"166","author":[{"given":"Shin","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, University of Tokyo , Tokyo ,","place":["Japan"]},{"name":"Molecular Preventive Medicine, and Core Research for Evolutional Science and Technology, School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Molecular Preventive Medicine, and Core Research for Evolutional Science and Technology, School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Izumizaki","sequence":"additional","affiliation":[{"name":"Second Department of Physiology, Showa University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yoshie","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Homma","sequence":"additional","affiliation":[{"name":"Second Department of Physiology, Showa University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Molecular Preventive Medicine, and Core Research for Evolutional Science and Technology, School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"key":"2026020209122421700_R1","first-page":"563","volume-title":"J. 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