{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:14:11Z","timestamp":1770088451844,"version":"3.49.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Among other features, peptides affect MHC class II molecules, causing changes in the binding of bacterial superantigens (b-Sag). Whether peptides can alter binding of viral superantigens (v-Sag) to MHC class II was not known. Here we addressed the question of whether mutations limiting the diversity of peptides bound by the MHC class II molecules influenced the presentation of v-Sag and, subsequently, the life cycle of the mouse mammary tumor virus (MMTV). T cells reactive to v-Sag were found in mice lacking DM molecules as well as in AbEp-transgenic mice in which MHC class II binding grooves were predominantly occupied by an invariant chain fragment or E\u03b152\u201368 peptide, respectively. APCs from the mutant mice failed to present v-Sag, as determined by the lack of Sag-specific T cell activation, Sag-induced T cell deletion, and by the aborted MMTV infection. In contrast, mice that express I-Ab with a variety of bound peptides presented v-Sag and were susceptible to MMTV infection. Comparison of v-Sag and b-Sag presentation by the same mutant cells suggested that presentation of v-Sag had requirements similar to that for presentation of toxic shock syndrome toxin-1. Thus, MHC class II peptide repertoire is critical for recognition of v-Sag by the T cells and affects the outcome of infection with a retrovirus.<\/jats:p>","DOI":"10.4049\/jimmunol.166.4.2244","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:56:08Z","timestamp":1398034568000},"page":"2244-2250","source":"Crossref","is-referenced-by-count":8,"title":["Diverse Repertoire of the MHC Class II-Peptide Complexes Is Required for Presentation of Viral Superantigens"],"prefix":"10.1093","volume":"166","author":[{"given":"Tatyana V","family":"Golovkina","sequence":"first","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Agafonova","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609"},{"name":"Institute of Carcinogenesis, Cancer Research Center , Moscow ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Kazansky","sequence":"additional","affiliation":[{"name":"Institute of Carcinogenesis, Cancer Research Center , Moscow ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Chervonsky","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,2,15]]},"reference":[{"key":"2026020209131008200_R1","first-page":"134","volume-title":"Nature","year":"1991"},{"key":"2026020209131008200_R2","first-page":"361","volume-title":"Semin. 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Virol.","year":"1997"},{"key":"2026020209131008200_R23","first-page":"1553","volume-title":"J. Immunol.","year":"1994"},{"key":"2026020209131008200_R24","first-page":"439","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020209131008200_R25","first-page":"5294","volume-title":"Biochemistry","year":"1979"},{"key":"2026020209131008200_R26","first-page":"662","volume-title":"J. Immunol.","year":"1984"},{"key":"2026020209131008200_R27","first-page":"940","volume-title":"J. Immunol.","year":"1980"},{"key":"2026020209131008200_R28","first-page":"63","volume-title":"Immunol. Rev.","year":"1979"},{"key":"2026020209131008200_R29","first-page":"29","volume-title":"Immunol. Rev.","year":"1983"},{"key":"2026020209131008200_R30","first-page":"269","volume-title":"Scand. J. Immunol.","year":"1999"},{"key":"2026020209131008200_R31","first-page":"187","volume-title":"Immunity","year":"1997"},{"key":"2026020209131008200_R32","first-page":"197","volume-title":"Immunity","year":"1997"},{"key":"2026020209131008200_R33","first-page":"660","volume-title":"Nature","year":"1991"},{"key":"2026020209131008200_R34","first-page":"2133","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020209131008200_R35","first-page":"2375","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020209131008200_R36","first-page":"1102","volume-title":"Eur. J. Immunol.","year":"1994"},{"key":"2026020209131008200_R37","first-page":"7690","volume-title":"J. Virol.","year":"1993"},{"key":"2026020209131008200_R38","first-page":"711","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209131008200_R39","first-page":"1267","volume-title":"Mol. Immunol.","year":"1996"},{"key":"2026020209131008200_R40","first-page":"225","volume-title":"J. 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