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We have recently established transgenic mice expressing Smad7, an inhibitor of TGF-\u03b2 signaling, in mature T cells, where signaling by TGF-\u03b2 was blocked specifically in T cells. In this study, we showed that anti-GBM Ab-induced GN was suppressed in several measures in the transgenic mice including the severity of glomerular changes, proteinuria, renal function, and CD4 T cell infiltration into the glomeruli without down-regulation of CD62 ligand (CD62L) (L-selectin) expression on CD4 T cells. Furthermore, treatment with the soluble fusion protein of CD62L and IgG enhanced anti-GBM Ab-induced GN. These findings indicated that blockade of TGF-\u03b2 signaling in T cells prevented the development of anti-GBM Ab-induced GN. Because CD62L on T cells appears to be inhibitory for the development of anti-GBM Ab-induced GN, persistent expression of CD62L on CD4 T cells may explain, at least in part, the suppression of anti-GBM Ab-induced GN in the transgenic mice. Our findings suggest that the development of anti-GBM Ab-induced GN requires TGF-\u03b2\/Smad signaling in T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.166.4.2818","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:56:08Z","timestamp":1398034568000},"page":"2818-2823","source":"Crossref","is-referenced-by-count":35,"title":["Blockade of TGF-\u03b2 Signaling in T Cells Prevents the Development of Experimental Glomerulonephritis"],"prefix":"10.1093","volume":"166","author":[{"given":"Yutaka","family":"Kanamaru","sequence":"first","affiliation":[{"name":"Allergy Research Center , Tokyo ,","place":["Japan"]},{"name":"Division of Nephrology Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhito","family":"Nakao","sequence":"additional","affiliation":[{"name":"Allergy Research Center , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuko","family":"Mamura","sequence":"additional","affiliation":[{"name":"Allergy Research Center , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Nephrology Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Shirato","sequence":"additional","affiliation":[{"name":"Division of Nephrology Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[{"name":"Allergy Research Center , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Tomino","sequence":"additional","affiliation":[{"name":"Division of Nephrology Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisei","family":"Ra","sequence":"additional","affiliation":[{"name":"Allergy Research Center , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,2,15]]},"reference":[{"key":"2026020209144756600_R1","volume-title":"The Kidney","year":"1991"},{"key":"2026020209144756600_R2","first-page":"69","volume-title":"Kidney Int.","year":"1994"},{"key":"2026020209144756600_R3","first-page":"2263","volume-title":"J. 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