{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:54:42Z","timestamp":1770090882131,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously studied the lung V\u03b2 TCR repertoire of C57BL\/6 mice during primary infection with the pathogen Histoplasma capsulatum. We observed a consistent oligoclonal expansion of V\u03b24+ T cells during the peak of infection and early stages of resolution. The V\u03b24+ family played a role in protective immunity against the fungus. Depletion of this subpopulation of T cells hindered optimal clearance of infection from tissues. In this report we analyze the flux of the V\u03b2 TCR repertoire in the lungs of C57BL\/6 mice with reinfection histoplasmosis. We observed a significant increase in V\u03b26+ T cells on days 7, 10, and 14, the peak and early resolution phases of infection. This skewing was preceded by an increased number of memory T cells within V\u03b26+ cells. The VDJ sequences of V\u03b26 chains were oligoclonal during the early stages of the infection, suggesting that the expansion was driven by a small number of Ags. More than 96% of the expanded V\u03b26+ cells were CD4+. Depletion of V\u03b26+ T cells but not V\u03b24+ T cells induced a modest but significant delay in fungal clearance. Simultaneous depletion of V\u03b24+ and V\u03b26+ T cells induced a more pronounced impairment of host resistance. These studies illustrate the dynamic interactions between V\u03b2 families in the response to microbial challenge.<\/jats:p>","DOI":"10.4049\/jimmunol.166.4.2855","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:56:08Z","timestamp":1398034568000},"page":"2855-2862","source":"Crossref","is-referenced-by-count":13,"title":["V\u03b26+ and V\u03b24+ T Cells Exert Cooperative Activity in Clearance of Secondary Infection with\n                    <i>Histoplasma capsulatum<\/i>"],"prefix":"10.1093","volume":"166","author":[{"given":"Francisco J","family":"Gomez","sequence":"first","affiliation":[{"name":"Research Division, Veterans Administration Medical Center , Cincinnati, OH 45202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin O","family":"Woodward","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati School of Medicine , Cincinnati, OH 45267"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Pilcher-Roberts","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati School of Medicine , Cincinnati, OH 45267"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reta S","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati School of Medicine , Cincinnati, OH 45267"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"George S","family":"Deepe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati School of Medicine , Cincinnati, OH 45267"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,2,15]]},"reference":[{"key":"2026020209125879900_R1","first-page":"973","volume-title":"Infect. Immun.","year":"1978"},{"key":"2026020209125879900_R2","first-page":"219","volume-title":"Arch. Med. Res.","year":"1993"},{"key":"2026020209125879900_R3","first-page":"13","volume-title":"South. Med. J.","year":"1973"},{"key":"2026020209125879900_R4","first-page":"714","volume-title":"Infect. Immun.","year":"1993"},{"key":"2026020209125879900_R5","first-page":"201","volume-title":"J. Lab. Clin. Med.","year":"1994"},{"key":"2026020209125879900_R6","first-page":"181","volume-title":"J. Med. Vet. Mycol.","year":"1993"},{"key":"2026020209125879900_R7","first-page":"3491","volume-title":"J. Immunol.","year":"1994"},{"key":"2026020209125879900_R8","first-page":"1685","volume-title":"Infect. Immun.","year":"1988"},{"key":"2026020209125879900_R9","first-page":"7389","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209125879900_R10","first-page":"1473","volume-title":"Infect. Immun.","year":"1998"},{"key":"2026020209125879900_R11","first-page":"984","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2026020209125879900_R12","first-page":"6072","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020209125879900_R13","first-page":"4459","volume-title":"Infect. Immun.","year":"1991"},{"key":"2026020209125879900_R14","first-page":"1371","volume-title":"J. Exp. Med.","year":"1991"},{"key":"2026020209125879900_R15","first-page":"189","volume-title":"Immunity","year":"1996"},{"key":"2026020209125879900_R16","first-page":"1457","volume-title":"Science","year":"1993"},{"key":"2026020209125879900_R17","first-page":"762","volume-title":"Eur. J. Immunol.","year":"1999"},{"key":"2026020209125879900_R18","first-page":"61","volume-title":"J. Exp. Med.","year":"1998"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/166\/4\/2855\/62537013\/2855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/166\/4\/2855\/62537013\/2855.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:17:30Z","timestamp":1770041850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/166\/4\/2855\/8025667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,2,15]]},"published-print":{"date-parts":[[2001,2,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.166.4.2855","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,2]]},"published":{"date-parts":[[2001,2]]}}}