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The functional relevance of A-myb expression at three of these sites has been demonstrated previously via the generation and analysis of A-myb-deficient mice, which display behavioral abnormalities, male sterility, and perturbed breast development during pregnancy. In contrast, here we show that the germinal center response driven by T cell-dependent Ag immunization and the associated processes of Ab V gene somatic hypermutation, affinity maturation, and heavy chain class switching are overtly normal in A-myb-deficient mice. Nonetheless, these mice display mild splenic white pulp hypoplasia and blunted primary serum Ab responses, suggesting that although A-myb is not directly involved in the regulation of the memory B cell response, it may play a role in enhancing peripheral B cell survival or proliferative capacity.<\/jats:p>","DOI":"10.4049\/jimmunol.166.5.3226","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:20:12Z","timestamp":1398036012000},"page":"3226-3230","source":"Crossref","is-referenced-by-count":4,"title":["The T Cell-Dependent B Cell Immune Response and Germinal Center Reaction Are Intact in A-myb-Deficient Mice"],"prefix":"10.1093","volume":"166","author":[{"given":"Kalpit A","family":"Vora","sequence":"first","affiliation":[{"name":"Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky M","family":"Lentz","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Monsell","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambasiva P","family":"Rao","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mettus","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Department of Biochemistry, Temple University Medical School , Philadelphia, PA 19140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Toscani","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Department of Biochemistry, Temple University Medical School , Philadelphia, PA 19140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Premkumar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Department of Biochemistry, Temple University Medical School , Philadelphia, PA 19140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Manser","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2026020208053295900_R1","first-page":"11075","volume-title":"Nucleic Acids Res.","year":"1988"},{"key":"2026020208053295900_R2","first-page":"113","volume-title":"Semin. 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