{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:41Z","timestamp":1791405221806,"version":"4.3.3"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in \u223c3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing glutamic acid (Glu) at position 69 in the HLA-DP\u03b2-chain. T cell clones were raised from three patients with CBD in whom exposure occurred 10 and 30 years previously. Of 25 Be-specific clones that were obtained, all were restricted by HLA-DP alleles with Glu at DP\u03b269. Furthermore, the proliferative responses of the clones were absolutely dependent upon DP\u03b2 Glu69 in that a single amino acid substitution at this position abolished the response. As befits a disease whose pathogenesis involves a delayed type hypersensitivity response, the large majority of Be-specific clones secreted IFN-\u03b3 (Th1) and little or no IL-4 (Th2) cytokines. This study provides insights into the molecular basis of DP2-associated susceptibility to CBD.<\/jats:p>","DOI":"10.4049\/jimmunol.166.5.3549","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:20:12Z","timestamp":1398036012000},"page":"3549-3555","source":"Crossref","is-referenced-by-count":88,"title":["HLA-DP Allele-Specific T Cell Responses to Beryllium Account for DP-Associated Susceptibility to Chronic Beryllium Disease"],"prefix":"10.1093","volume":"166","author":[{"given":"Giovanna","family":"Lombardi","sequence":"first","affiliation":[{"name":"Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Germain","sequence":"additional","affiliation":[{"name":"Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Uren","sequence":"additional","affiliation":[{"name":"Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Development, University \u201cLa Sapienza\u201d , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M","family":"du Bois","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jones-Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wales College of Medicine , Cardiff ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Saltini","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases of the University of \u201cTor Vergata\u201d at the L. 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