{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:24:07Z","timestamp":1770078247125,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eukaryotic translation initiation factor (eIF)-6 is known to be important in ribosome biogenesis. Previously, we have discovered that eIF-6 mRNA is induced in lung in a murine model of asthma. We also found that there was enhanced eIF-6 expression in mast cells stimulated with PMA plus calcium ionophore. Therefore, we hypothesized that the induction of eIF-6 enhances the production of bioactive mediators by mast cells upon allergic stimulation. In the current study, we found that eIF-6 mRNA was rapidly induced in murine mast cells stimulated by Fc\u03b5RI cross-linking, which is a major physiologic stimulant for mast cells. eIF-6 was also induced in human mast cells upon stimulation. The increase in eIF-6 gene expression in murine mast cells was blocked by therapeutic agents such as dexamethasone and cyclosporin A. To determine the location and function of eIF-6, murine mast cells were transfected with a construct that overexpressed enhanced green fluorescent protein-tagged eIF-6. These experiments demonstrated that eIF-6 was localized predominantly in the nucleolus of the mast cells. Also, overexpression of enhanced green fluorescent protein\/eIF-6 enhanced the production of histamine and IL-2, but not IL-4 by stimulated murine mast cells. These results suggest that eIF-6 regulates the production of selected bioactive mediators in allergic diseases. This is the first demonstration of a biologic function of eIF-6 in mammalian cells.<\/jats:p>","DOI":"10.4049\/jimmunol.166.5.3606","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:20:12Z","timestamp":1398036012000},"page":"3606-3611","source":"Crossref","is-referenced-by-count":14,"title":["Eukaryotic Translation Initiation Factor-6 Enhances Histamine and IL-2 Production in Mast Cells"],"prefix":"10.1093","volume":"166","author":[{"given":"Chad K","family":"Oh","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Harbor-University of California, Los Angeles, Medical Center , Torrance, CA 90509"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott G","family":"Filler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Harbor-University of California, Los Angeles, Medical Center , Torrance, CA 90509"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong H","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Harbor-University of California, Los Angeles, Medical Center , Torrance, CA 90509"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2026020208024755200_R1","first-page":"325","volume-title":"Exp. 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