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By using antigenic peptides and lipids that were fluorescently labeled, we found that CTLs promptly capture target cell membranes together with the antigenic peptide as well as various other surface proteins. This efficient and specific capture process requires sustained TCR signaling. Our observations indicate that this process allows efficient acquisition of the Ag by CTL, which may in turn regulate lymphocyte activation or elimination.<\/jats:p>","DOI":"10.4049\/jimmunol.166.6.3645","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:32:32Z","timestamp":1398022352000},"page":"3645-3649","source":"Crossref","is-referenced-by-count":181,"title":["Cutting Edge: CTLs Rapidly Capture Membrane Fragments from Target Cells in a TCR Signaling-Dependent Manner"],"prefix":"10.1093","volume":"166","author":[{"given":"Denis","family":"Hudrisier","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 395, Centre Hospitalier Universitaire Purpan, BP3028 , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Riond","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 5089 , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honore\u0301","family":"Mazarguil","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 5089 , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Edouard","family":"Gairin","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 5089 , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Joly","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Propre de Recherche 2163, Centre Hospitalier Universitaire Purpan, BP3028 , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,3,15]]},"reference":[{"key":"2026020208101291200_R1","first-page":"148","volume-title":"Nature","year":"1995"},{"key":"2026020208101291200_R2","first-page":"952","volume-title":"Science","year":"1999"},{"key":"2026020208101291200_R3","first-page":"1137","volume-title":"J. 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