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We show here by using the rat insulin promotor lymphocytic choriomeningitis virus glycoprotein model of autoimmune diabetes that the activation of self-reactive CTL by DC after uptake of exogenous Ag is very limited, first by the short half-life of MHC class I-associated peptides on DC in vitro and in vivo, and second by the rather inefficient MHC class I presentation of cell-associated self-Ags by DC. These two mechanisms are probably crucial in establishing high thresholds for the induction of self-reactive CTL that prevent autoimmune sequelae after release of sequestered and previously immunologically ignored tissue Ags.<\/jats:p>","DOI":"10.4049\/jimmunol.166.6.3678","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:32:32Z","timestamp":1398022352000},"page":"3678-3687","source":"Crossref","is-referenced-by-count":66,"title":["Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells"],"prefix":"10.1093","volume":"166","author":[{"given":"Burkhard","family":"Ludewig","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"McCoy","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Pericin","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian F","family":"Ochsenbein","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Dumrese","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Odermatt","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene E M","family":"Toes","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Bank, University of Leiden , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis J M","family":"Melief","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Bank, University of Leiden , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf M","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, Department of Pathology, University of Zu\u0308rich , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,3,15]]},"reference":[{"key":"2026020208043920600_R1","first-page":"1","volume-title":"Adv. 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