{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:12Z","timestamp":1790810892266,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We studied the expression of normal cellular prion protein (PrPC) in mouse lymphoid tissues with newly developed mAbs to PrPC. Most of the mature T and B cells in the peripheral lymphoid organs do not express PrPC. In contrast, most thymocytes are PrPC+. In the bone marrow, erythroid cells and maturing granulocytes are PrPC+. Approximately 50% of the cells in the region of small lymphocytes and progenitor cells also express PrPC. Most of these PrPC+ cells are CD43+, but B220\u2212, surface IgM\u2212 (sIgM\u2212), and IL-7R\u2212, a phenotype that belongs to cells not yet committed to the B cell lineage. Another small group of the PrPC+ cell are B220+, and some of these are also sIgM+. The majority of the B220+ cells, however, are PrPC\u2212. Therefore, PrPC is preferentially expressed in early bone marrow progenitor cells and subsets of maturing B cells. Supporting this interpretation is our observation that stimulation of bone marrow cells in vitro with PMA results in a decrease in the number of PrPC+B220\u2212 cells with a corresponding increase of sIgM+B220high mature B cells. This result suggests that the PrPC+B220\u2212 cells are potential progenitors. Furthermore, in the bone marrow of Rag-1\u2212\/\u2212 mice, there are an increased number of PrPC+B220\u2212 cells, and most of the developmentally arrested pro-B cells in these mice are PrPC+. Collectively, these results suggest that PrPC is expressed preferentially in immature T cells in the thymus and early progenitor cells in the bone marrow, and the expression of PrPC is regulated during hemopoietic differentiation.<\/jats:p>","DOI":"10.4049\/jimmunol.166.6.3733","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:32:32Z","timestamp":1398022352000},"page":"3733-3742","source":"Crossref","is-referenced-by-count":49,"title":["Normal Cellular Prior Protein Is Preferentially Expressed on Subpopulations of Murine Hemopoietic Cells"],"prefix":"10.1093","volume":"166","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruliang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon-Seng","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacai","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Petersen","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"},{"name":"Division of Neuropathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Gambetti","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"},{"name":"Division of Neuropathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Sun","family":"Sy","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"},{"name":"Cancer Research Center, School of Medicine, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,3,15]]},"reference":[{"key":"2026020208083497800_R1","first-page":"337","volume-title":"Cell","year":"1998"},{"key":"2026020208083497800_R2"},{"key":"2026020208083497800_R3","first-page":"229","volume-title":"Cell","year":"1987"},{"key":"2026020208083497800_R4","first-page":"2799","volume-title":"FASEB J.","year":"1991"},{"key":"2026020208083497800_R5","first-page":"2851","volume-title":"Virology","year":"1996"},{"key":"2026020208083497800_R6","first-page":"1994","volume-title":"N. 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