{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:09:31Z","timestamp":1770084571055,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have investigated the reactivities of cytotoxic T (Tc) cells against the two immunodominant, H-2Kk-restricted determinants from the Flavivirus Murray Valley encephalitis virus (MVE), MVE1785 (REHSGNEI) and MVE1971 (DEGEGRVI). The respective Tc cell populations cross-reactively lysed target cells pulsed with determinants from the MVE1785- and MVE1971-corresponding positions of six other flaviviruses, despite low sequence homology in some cases. Notably, anti-MVE1785 Tc cells recognized a determinant (TDGEERVI) that shares with the determinant used for stimulation only the carboxyl-terminal amino acid residue, one of two H-2Kk anchor residues. These reactivity patterns were also observed in peptide-dependent IFN-\u03b3 production and the requirements for in vitro restimulation of memory Tc cells. However, the broad cross-reactivity appeared to be limited to flavivirus-derived determinants, as none of a range of determinants from endogenous mouse-derived sequences, similar to the MVE-determinants, were recognized. Neither were cells infected with a number of unrelated viruses recognized. These results raise the paradox that virus-immune Tc cell responses, which are mostly directed against only a few \u201cimmunodominant\u201d viral determinants, are remarkably peptide cross-reactive.<\/jats:p>","DOI":"10.4049\/jimmunol.166.6.3820","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:32:32Z","timestamp":1398022352000},"page":"3820-3828","source":"Crossref","is-referenced-by-count":19,"title":["Antiviral Cytotoxic T Cells Cross-Reactively Recognize Disparate Peptide Determinants from Related Viruses but Ignore More Similar Self- and Foreign Determinants"],"prefix":"10.1093","volume":"166","author":[{"given":"Matthias","family":"Regner","sequence":"first","affiliation":[{"name":"Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Lobigs","sequence":"additional","affiliation":[{"name":"Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert V","family":"Blanden","sequence":"additional","affiliation":[{"name":"Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Milburn","sequence":"additional","affiliation":[{"name":"Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Mu\u0308llbacher","sequence":"additional","affiliation":[{"name":"Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,3,15]]},"reference":[{"key":"2026020208062820600_R1","first-page":"369","volume-title":"Annu. 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