{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:49:30Z","timestamp":1790434170182,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human T cell leukemia virus type I (HTLV-I) and HIV-1, causative agents of adult T cell leukemia\/lymphoma and AIDS, respectively, are transmitted vertically via breast milk. Here we demonstrate that lactoferrin, a milk protein that has a variety of antimicrobial and immunomodulatory activities, facilitates replication of HTLV-I in lymphocytes derived from asymptomatic HTLV-I carriers and transmission to cord blood lymphocytes in vitro. Transient expression assays revealed that lactoferrin can transactivate HTLV-I long terminal repeat promoter. In contrast, lactoferrin inhibits HIV-1 replication, at least in part, at the level of viral fusion\/entry. These results suggest that lactoferrin may have different effects on vertical transmission of the two milk-borne retroviruses.<\/jats:p>","DOI":"10.4049\/jimmunol.166.6.4231","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:32:32Z","timestamp":1398036752000},"page":"4231-4236","source":"Crossref","is-referenced-by-count":60,"title":["A Milk Protein Lactoferrin Enhances Human T Cell Leukemia Virus Type I and Suppresses HIV-1 Infection"],"prefix":"10.1093","volume":"166","author":[{"given":"Masako","family":"Moriuchi","sequence":"first","affiliation":[{"name":"Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences , Nagasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences , Nagasaki ,","place":["Japan"]},{"name":"Department of Pediatrics, Nagasaki University School of Medicine , Nagasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,3,15]]},"reference":[{"key":"2025032713593249600_R1","first-page":"1173","volume-title":"N. 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