{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:40:49Z","timestamp":1770082849603,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Histocompatibility (H) Ags are responsible for chronic graft rejection and graft vs host disease in solid tissue and bone marrow transplantation among MHC-matched individuals. Here we defined the molecular basis of self-nonself discrimination for the murine chromosome 7 encoded H47 histocompatibility locus, known by its trait of graft-rejection for over 40 years. H47 encodes a novel, highly conserved cell surface protein containing the SCILLYIVI (SII9) nonapeptide in its transmembrane region. The p7 isoleucine-to-phenylalanine substitution in SII9 defined the antigenic polymorphism and T cell specificity. Despite absence of the canonical consensus motif and weak binding to Db MHC I, both H47 peptides were presented to CTLs. However, unlike all the other known H loci, the relative immunogenicity of both H47 alleles varied dramatically and was profoundly influenced by neighboring H loci. The results provide insights into the peptide universe that defines nonself and the basis of histoincompatibility.<\/jats:p>","DOI":"10.4049\/jimmunol.166.7.4438","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:32:21Z","timestamp":1398025941000},"page":"4438-4445","source":"Crossref","is-referenced-by-count":24,"title":["Distinguishing Self from Nonself: Immunogenicity of the Murine\n                    <i>H47<\/i>\n                    Locus Is Determined by a Single Amino Acid Substitution in an Unusual Peptide"],"prefix":"10.1093","volume":"166","author":[{"given":"Lisa M","family":"Mendoza","sequence":"first","affiliation":[{"name":"Division of Immunology, Department of Molecular and Cell Biology, University of California , Berkeley, CA 94720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Villaflor","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular and Cell Biology, University of California , Berkeley, CA 94720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eden","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derry","family":"Roopenian","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilabh","family":"Shastri","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular and Cell Biology, University of California , Berkeley, CA 94720"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2026020208032010100_R1","first-page":"904","volume-title":"Science","year":"1914"},{"key":"2026020208032010100_R2","first-page":"87","volume-title":"J. 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