{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:25:59Z","timestamp":1790839559946,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The role of apoptosis in regulating the course of intracellular microbial infection is not well understood. We studied the relationship between apoptotic regulation and bacillus Calmette-Gue\u0301rin (BCG) treatment in murine peritoneal exudate macrophages (PEM) and the J774 macrophage cell line. In both PEM and J774 cells, mRNA expression of the anti-apoptotic gene, A1, was selectively induced by BCG treatment as compared with other bcl2 family members (bcl-w, bcl-2, bcl-xl, bcl-xs, bax, bak, bad). In PEM, A1 expression was maximal by 8 h postinfection and was abrogated by the proteasomal inhibitor MG-132. The induction was independent of protein synthesis as well as the p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways and did not require live organism. Three genes encoding closely related isoforms of A1 were all expressed; however, the A1-a isoform displayed the greatest fold induction in PEM. BCG-induced A1 expression was associated with protection of host macrophages from NO-mediated apoptosis in both PEM and J774 cells. BCG-mediated protection was abrogated in PEM derived from A1-a\u2212\/\u2212 mice, indicating a requirement of A1-a for survival of inflammatory macrophages.<\/jats:p>","DOI":"10.4049\/jimmunol.166.7.4721","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:32:21Z","timestamp":1398025941000},"page":"4721-4727","source":"Crossref","is-referenced-by-count":34,"title":["Requirement of\n                    <i>A1-a<\/i>\n                    for Bacillus Calmette-Gue\u0301rin-Mediated Protection of Macrophages Against Nitric Oxide-Induced Apoptosis"],"prefix":"10.1093","volume":"166","author":[{"given":"Santhanam","family":"Kausalya","sequence":"first","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Somogyi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Orlofsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B","family":"Prystowsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2026020208020349100_R1","first-page":"127","volume-title":"J. 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