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While a number of receptors involved in the cognate recognition of apoptotic cells by phagocytes have been identified, the signaling events that result in internalization remain poorly understood. Here we demonstrate that clearance of apoptotic cells is accompanied by recruitment of the Wiskott-Aldrich syndrome (WAS) protein to the phagocytic cup and that it\u2019s absence results in delayed phagocytosis both in vitro and in vivo. Therefore, we propose that WAS protein plays an important and nonredundant role in the safe removal of apoptotic cells and that deficiency contributes significantly to the immune dysregulation of WAS. The efficiency of apoptotic cell clearance may be a key determinant in the suppression of tissue inflammation and prevention of autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.166.8.4831","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:57:27Z","timestamp":1398031047000},"page":"4831-4834","source":"Crossref","is-referenced-by-count":104,"title":["Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells"],"prefix":"10.1093","volume":"166","author":[{"given":"Yann","family":"Leverrier","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch , London ,","place":["United Kingdom"]},{"name":"Department of Biochemistry and Molecular Biology, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Molecular Haematology Unit, Institute of Child Health, University College London , London ,","place":["United Kingdom"]},{"name":"Molecular Immunology Unit, Institute of Child Health, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Blundell","sequence":"additional","affiliation":[{"name":"Molecular Immunology Unit, Institute of Child Health, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brickell","sequence":"additional","affiliation":[{"name":"Molecular Haematology Unit, Institute of Child Health, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kinnon","sequence":"additional","affiliation":[{"name":"Molecular Immunology Unit, Institute of Child Health, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J","family":"Ridley","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch , London ,","place":["United Kingdom"]},{"name":"Department of Biochemistry and Molecular Biology, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J","family":"Thrasher","sequence":"additional","affiliation":[{"name":"Molecular Immunology Unit, Institute of Child Health, University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,4,15]]},"reference":[{"key":"2026020209184909600_R1","first-page":"365","volume-title":"Trends Cell Biol.","year":"1998"},{"key":"2026020209184909600_R2","first-page":"563","volume-title":"Cell Death Differ.","year":"1998"},{"key":"2026020209184909600_R3","first-page":"890","volume-title":"J. 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