{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:32:08Z","timestamp":1791415928240,"version":"4.3.3"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antibiotic treatment-resistant Lyme arthritis is a chronic inflammatory joint disease that follows infection with Borrelia burgdorferi (Bb). A marked Ab and T cell response to Bb outer surface protein A (OspA) often develops during prolonged episodes of arthritis. Furthermore, cross-reaction between the bacterial OspA and human LFA-1\u03b1L at the T cell level and the inability to detect Bb in the joint implicate an autoimmune mechanism. To analyze the nature of response to OspA and LFA-1\u03b1L, we used OspA-specific T cell hybrids from DR4 transgenic mice, as well as cloned human cells specific for OspA165\u2013184, the immunodominant epitope, from five DRB1*0401+ patients, using OspA-MHC class II tetramers. Although OspA165\u2013184 stimulated nearly all OspA-specific human T cell clones tested to proliferate and secrete IFN-\u03b3 and IL-13, LFA-1\u03b1L326\u2013345 stimulated \u223c10% of these clones to proliferate and a greater percentage to secrete IL-13. Assays with LFA- or OspA-DR4 monomers revealed that higher concentrations of LFA-DR4 were needed to stimulate dual-reactive T cell hybrids. Our analysis at the clonal level demonstrates that human LFA-1\u03b1L326\u2013345 behaves as a partial agonist, perhaps playing a role in perpetuating symptoms of arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.166.8.5286","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:57:27Z","timestamp":1398031047000},"page":"5286-5291","source":"Crossref","is-referenced-by-count":98,"title":["Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1\u03b1L Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells"],"prefix":"10.1093","volume":"166","author":[{"given":"Christina","family":"Trollmo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie L","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine, New England Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C","family":"Steere","sequence":"additional","affiliation":[{"name":"Division of Rheumatology\/Immunology, Tufts University School of Medicine, New England Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Hafler","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte T","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine, New England Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,4,15]]},"reference":[{"key":"2026020209184567300_R1","first-page":"291","volume-title":"Cell","year":"1996"},{"key":"2026020209184567300_R2","first-page":"387","volume-title":"Baillieres Clin. Neurol.","year":"1997"},{"key":"2026020209184567300_R3","first-page":"675","volume-title":"Immunity","year":"1998"},{"key":"2026020209184567300_R4","first-page":"94","volume-title":"Science","year":"1996"},{"key":"2026020209184567300_R5","first-page":"291","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020209184567300_R6","first-page":"R63","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2026020209184567300_R7"},{"key":"2026020209184567300_R8","first-page":"107","volume-title":"Lyme Disease","year":"1998"},{"key":"2026020209184567300_R9","first-page":"63","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020209184567300_R10","first-page":"878","volume-title":"Arthritis Rheum.","year":"1994"},{"key":"2026020209184567300_R11","first-page":"2774","volume-title":"Infect. Immun.","year":"1993"},{"key":"2026020209184567300_R12","first-page":"2228","volume-title":"Infect. Immun.","year":"1995"},{"key":"2026020209184567300_R13","first-page":"S81","volume-title":"Arthritis Rheum.","year":"1998"},{"key":"2026020209184567300_R14","first-page":"703","volume-title":"Science","year":"1998"},{"key":"2026020209184567300_R15","first-page":"211","volume-title":"Trends Microbiol.","year":"1998"},{"key":"2026020209184567300_R16","first-page":"1335","volume-title":"Science","year":"1999"},{"key":"2026020209184567300_R17","first-page":"1344","volume-title":"Science","year":"1998"},{"key":"2026020209184567300_R18","first-page":"20","volume-title":"Morbid. Mortal. Wkly. Rep.","year":"1997"},{"key":"2026020209184567300_R19","first-page":"590","volume-title":"Morbid. Mortal. Wkly. Rep.","year":"1995"},{"key":"2026020209184567300_R20"},{"key":"2026020209184567300_R21","first-page":"229","volume-title":"N. Engl. J. Med.","year":"1994"},{"key":"2026020209184567300_R22","first-page":"151","volume-title":"Nature","year":"1994"},{"key":"2026020209184567300_R23","first-page":"2635","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209184567300_R24","first-page":"199","volume-title":"Cytometry","year":"1998"},{"key":"2026020209184567300_R25","first-page":"1022","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020209184567300_R26","first-page":"2705","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2026020209184567300_R27","first-page":"1847","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209184567300_R28","first-page":"1375","volume-title":"Nat. Med.","year":"1999"},{"key":"2026020209184567300_R29","first-page":"1229","volume-title":"J. Exp. Med.","year":"1987"},{"key":"2026020209184567300_R30","first-page":"1","volume-title":"Int. Rev. Immunol.","year":"1998"},{"key":"2026020209184567300_R31","first-page":"2585","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020209184567300_R32","first-page":"163","volume-title":"Immunol. Today","year":"1998"},{"key":"2026020209184567300_R33","first-page":"6424","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209184567300_R34","first-page":"338","volume-title":"J. Pept. Res.","year":"1998"},{"key":"2026020209184567300_R35","first-page":"448","volume-title":"Eur. J. Immunol.","year":"2000"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/166\/8\/5286\/62530650\/5286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/166\/8\/5286\/62530650\/5286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:26:13Z","timestamp":1770042373000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/166\/8\/5286\/8027092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2001,4,15]]},"published-print":{"date-parts":[[2001,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.166.8.5286","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,4]]},"published":{"date-parts":[[2001,4]]}}}