{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:32:06Z","timestamp":1770751926880,"version":"3.50.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spontaneous germinal center (GC)-derived B cell lymphomas of SJL mice (RCS) transcribe a 1.8-kb Mtv-29 mRNA under control of the META-env promoter. The encoded vSAg29 stimulates syngeneic V\u03b216+ CD4+ T cells, thereby acquiring T cell help necessary for RCS growth. Other strains of B cell lymphoma-prone mice include Mtv29+ C57L and MA\/MyJ, and the Mtv29\u2212 \u00a0Mtv7+-recombinant inbred strain, SW \u00d7 J-1. The lymphomas of these mice produce similar mouse mtv-vSAg-encoding mRNA, as characterized by Northern blotting, PCR, and RNase protection. A 1.8-kb mRNA in C57L\/J and MA\/MyJ lymphomas hybridized with an Mtv29-specific oligonucleotide, whereas SW \u00d7 J-1 lymphomas produced 1.8-kb transcripts hybridizing with an Mtv7-specific oligonucleotide. Similar META-env-initiated transcripts were absent from LPS-activated B cells from any strain examined but were detected in Peyer\u2019s patch RNA from SJL mice. Like typical SJL-derived RCS, all these lymphomas stimulated syngeneic CD4+ T cells and V\u03b216+ T hybridoma cells. Immunohistochemical staining of primary tumors showed the presence of peanut agglutinin binding (PNA+) highly mitotic lymphoblasts, suggesting their GC derivation. The findings indicate that this novel mRNA for Mtv29 is present in B cell lymphomas from several Mtv29+ mouse strains. Additionally, this is the first description of the ability of Mtv7 to produce transcripts that are controlled and spliced identically to those of Mtv29 and that are expressed in SW \u00d7 J-1, I-As+, lymphomas that also stimulate V\u03b216+ T cells. Our results suggest an important role for mouse mtv-vSAgs and V\u03b216 T cell stimulation in the development of GC-derived murine B cell lymphomas.<\/jats:p>","DOI":"10.4049\/jimmunol.166.9.5422","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:42:04Z","timestamp":1398022924000},"page":"5422-5429","source":"Crossref","is-referenced-by-count":12,"title":["META-Controlled\n                    <i>env<\/i>\n                    -Initiated Transcripts Encoding Superantigens of Murine\n                    <i>Mtv29<\/i>\n                    and\n                    <i>Mtv7<\/i>\n                    and Their Possible Role in B Cell Lymphomagenesis"],"prefix":"10.1093","volume":"166","author":[{"given":"Namita","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School , Newark, NJ 07103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan M","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Erianne","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School , Newark, NJ 07103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson S","family":"Jaeggli","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School , Newark, NJ 07103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent K","family":"Tsiagbe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M","family":"Ponzio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School , Newark, NJ 07103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G Jeanette","family":"Thorbecke","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"2026020209160971800_R1","first-page":"422","volume-title":"Am. 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