{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:05:44Z","timestamp":1781816744598,"version":"3.54.5"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The glycosylphosphatidylinositol-anchored CD24 protein is a B cell differentiation Ag that is expressed on mature resting B cells but disappears upon Ag stimulation. We used Burkitt\u2019s lymphoma (BL) cells, which are thought to be related to germinal center B cells, to examine the biological effect of Ab-mediated CD24 cross-linking on human B cells and observed 1) induction of apoptosis in BL cells mediated by cross-linking of CD24; and 2) synergism between the cross-linking of CD24 and that of the B cell receptor for Ag in the effect on apoptosis induction. We also observed activation of mitogen-activated protein kinases following CD24 cross-linking, suggesting that CD24 mediates the intracellular signaling that leads to apoptosis in BL cells. Although CD24 has no cytoplasmic portion to transduce signals intracellularly, analysis of biochemically separated glycolipid-enriched membrane (GEM) fractions indicated enhanced association of CD24 and Lyn protein tyrosine kinase in GEM as well as increased Lyn kinase activity after CD24 cross-linking, suggesting that CD24 mediates intracellular signaling via a GEM-dependent mechanism. Specific microscopic cocapping of CD24 and Lyn, but not of other kinases, following CD24 cross-linking supported this idea. We further observed that apoptosis induction by cross-linking is a common feature shared by GEM-associated molecules expressed on BL cells, including GPI-anchored proteins and glycosphingolipids. CD24-mediated apoptosis in BL cells may provide a model for the cell death mechanism initiated by GEM-associated molecules, which is closely related to B cell receptor for Ag-mediated apoptosis.<\/jats:p>","DOI":"10.4049\/jimmunol.166.9.5567","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:42:04Z","timestamp":1398022924000},"page":"5567-5577","source":"Crossref","is-referenced-by-count":128,"title":["CD24 Induces Apoptosis in Human B Cells Via the Glycolipid-Enriched Membrane Domains\/Rafts-Mediated Signaling System"],"prefix":"10.1093","volume":"166","author":[{"given":"Toyo","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Pathology, National Children\u2019s Medical Research Center, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]},{"name":"Department of Pediatrics, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Kiyokawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children\u2019s Medical Research Center, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children\u2019s Medical Research Center, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Sekino","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children\u2019s Medical Research Center, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohko U","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children\u2019s Medical Research Center, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children\u2019s Medical Research Center, Juntendo University, School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"2026020209171403800_R1","first-page":"356","volume-title":"Immunol. 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