{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:18:40Z","timestamp":1790932720642,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Initiation of the pulmonary inflammatory response to Pneumocystis carinii is delayed by 3 wk in mice infected as neonates compared with adults. There was no difference in the proliferative response of draining lymph node T cells from mice infected as neonates compared with adults when stimulated in vitro with either Con A or anti-CD3 mAb. However, TNF-\u03b1 and IFN-\u03b3 mRNA expression in the lungs of P. carinii-infected neonates was significantly lower than in adults indicating a lack of appropriate activation signaling in the local environment. This may have been due to active suppression because TGF-\u03b2 mRNA expression was significantly elevated in neonatal lungs compared with adults. To determine whether T cells from 10-day-old mice would effect resolution of P. carinii if harbored in an adult lung environment, cells were adoptively transferred to SCID mice with established P. carinii infections. There was no difference in the kinetics of T cell migration into the lungs or of clearance of P. carinii organisms when SCID mice were reconstituted with splenocytes from young mice as compared with adult mice. Furthermore, splenocytes from young mice stimulated both TNF-\u03b1 and IFN-\u03b3 mRNA expression to levels that were similar to that in the lungs of SCID mice reconstituted with adult cells. These data indicate that neonatal lymphocytes are competent to resolve P. carinii infection when harbored in an adult lung environment, suggesting that the neonatal lung environment, and not the T cells, is ineffective at responding to P. carinii infection.<\/jats:p>","DOI":"10.4049\/jimmunol.166.9.5704","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:42:04Z","timestamp":1398022924000},"page":"5704-5711","source":"Crossref","is-referenced-by-count":44,"title":["Neonatal T Cells in an Adult Lung Environment Are Competent to Resolve\n                    <i>Pneumocystis carinii<\/i>\n                    Pneumonia"],"prefix":"10.1093","volume":"166","author":[{"given":"Mahboob H","family":"Qureshi","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine, Microbiology, and Immunology, Division of Infectious Diseases, University of Kentucky and Veterans Administration Medical Center , Lexington, KY 40506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A","family":"Garvy","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Microbiology, and Immunology, Division of Infectious Diseases, University of Kentucky and Veterans Administration Medical Center , Lexington, KY 40506"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"2026020209182878000_R1","first-page":"504","volume-title":"Am. 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