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All tetramer-binding CD45RA+ cells, regardless of epitope specificity, expressed a phenotype LFA-1highCCR7low that was stable for at least 10 years in infectious mononucleosis patients and indefinitely in asymptomatic carriers. CD8+CD45RA+LFA-1high cells were not present in cord blood but in adults account for up to 50% of CD8+CD45RA+ cells. These CD45RA+LFA-1high cells have significantly shorter telomeres than CD45RA+LFA-1low cells, suggesting that the latter represent a naive population, while the former are memory cells. CD45RA+ memory cells are a stable population of noncycling cells, but on stimulation they are potent producers of IFN-\u03b3, while naive CD8+ cells produce only IL-2. The chemokine receptor profile and migratory potential of CD45RA+ memory cells is very similar to CD45RO+ cells but different to naive CD8 cells. In accord with this, CD45RA+ memory cells were significantly underrepresented in lymph nodes, but account for virtually all CD8+CD45RA+ T cells in peripheral tissues of the same individuals.<\/jats:p>","DOI":"10.4049\/jimmunol.167.1.212","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:28:05Z","timestamp":1398025685000},"page":"212-220","source":"Crossref","is-referenced-by-count":126,"title":["Memory T Cells Constitute a Subset of the Human CD8+CD45RA+ Pool with Distinct Phenotypic and Migratory Characteristics"],"prefix":"10.1093","volume":"167","author":[{"given":"Jeffery M","family":"Faint","sequence":"first","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola E","family":"Annels","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S John","family":"Curnow","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Shields","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell","family":"Pilling","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Hislop","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wu","sequence":"additional","affiliation":[{"name":"Millennium Pharmaceuticals , Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne N","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Royal Free Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Buckley","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A H","family":"Moss","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Adams","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B","family":"Rickinson","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Salmon","sequence":"additional","affiliation":[{"name":"University of Birmingham\/Medical Research Council Centre for Immune Regulation, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2026020208124519000_R1","first-page":"54","volume-title":"Science","year":"1996"},{"key":"2026020208124519000_R2","first-page":"117","volume-title":"Annu. 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