{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:42Z","timestamp":1791405222427,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nickel (Ni) is one of the most common contact sensitizers in man, and Ni-induced contact dermatitis is considered as a model of hapten-induced delayed type hypersensitivity. Previous studies indicated that Ni-reactive T cells derived from Ni-allergic individuals preferentially express distinct TCR-V\u03b2 chains. However, data on the TCR-V\u03b2 repertoire of Ni-responsive T cells are not consistent. Therefore, the aim of this study was to identify the TCR-V\u03b2 receptors of Ni-responsive peripheral and cutaneous T cells in a cohort of 17 donors with Ni-induced contact dermatitis in comparison with those of 6 healthy controls. Peripheral NiSO4-responsive T lymphocytes showed a significant overexpression of TCR-V\u03b217 and the frequency of TCR-V\u03b217+ T cells correlated significantly with the in vitro reactivity of PBMC to NiSO4. In addition, the cutaneous infiltrate of Ni-induced patch test reactions consisted primarily of V\u03b217+ T cells. The majority of patch test-derived NiSO4-responsive T cells of three allergic donors were TCR-V\u03b217+, whereas patch test-derived NiSO4 unresponsive T cells of four additional donors did not express TCR-V\u03b217. Skin-derived Ni-responsive T cell lines from three donors uniformly secreted the Th2 cytokine, IL-5, but no IFN-\u03b3 or IL-10. These in vitro and in vivo findings strongly suggest that T cells with a restricted TCR-V\u03b2 repertoire, i.e., V\u03b217, predominate in NiSO4-induced contact dermatitis and may be crucial in the effector phase of Ni hypersensitivity.<\/jats:p>","DOI":"10.4049\/jimmunol.167.10.6038","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:17Z","timestamp":1398034517000},"page":"6038-6044","source":"Crossref","is-referenced-by-count":48,"title":["Preferential Usage of TCR-V\u03b217 by Peripheral and Cutaneous T Cells in Nickel-Induced Contact Dermatitis"],"prefix":"10.1093","volume":"167","author":[{"given":"Lioba","family":"Bu\u0308dinger","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rheinisch-Westfa\u0308lische Technische Hochschule , Aachen ,","place":["Germany"]},{"name":"Interdisciplinary Center for Clinical Research, Rheinisch-Westfa\u0308lische Technische Hochschule , Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Neuser","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rheinisch-Westfa\u0308lische Technische Hochschule , Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Totzke","sequence":"additional","affiliation":[{"name":"MDS Pharma Services , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans F","family":"Merk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rheinisch-Westfa\u0308lische Technische Hochschule , Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rheinisch-Westfa\u0308lische Technische Hochschule , Aachen ,","place":["Germany"]},{"name":"Department of Dermatology, University ofErlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,11,15]]},"reference":[{"key":"2026020208031927500_R1","first-page":"510","volume-title":"J. 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