{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:06:20Z","timestamp":1770087980207,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Expulsion of two gastrointestinal nematode parasites, Nippostrongylus brasiliensis and Trichinella spiralis, is similar in that both require IL-4R\u03b1 expression, but different in that T cells and mast cells are required for IL-4-induced expulsion of T. spiralis but not N. brasiliensis. To examine the role of IL-4R\u03b1 signaling in immunity to these parasites, we studied worm expulsion in chimeric mice that selectively expressed IL-4R\u03b1 on bone marrow-derived or non-bone marrow-derived cells. N. brasiliensis was expelled by mice that expressed IL-4R\u03b1 only on non-bone marrow-derived cells, but not by mice that expressed IL-4R\u03b1 only on bone marrow-derived cells. Although T. spiralis expulsion required IL-4R\u03b1 expression by both bone marrow- and non-bone marrow-derived cells, IL-4 stimulation eliminated the requirement for IL-4R\u03b1 expression by bone marrow-derived cells. Thus, direct IL-4R\u03b1 signaling of nonimmune gastrointestinal cells may be generally required to induce worm expulsion, even when mast cell and T cell responses are also required.<\/jats:p>","DOI":"10.4049\/jimmunol.167.11.6078","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:34Z","timestamp":1398024514000},"page":"6078-6081","source":"Crossref","is-referenced-by-count":75,"title":["Cutting Edge: IL-4 Receptor Expression by Non-Bone Marrow-Derived Cells Is Required to Expel Gastrointestinal Nematode Parasites"],"prefix":"10.1093","volume":"167","author":[{"suffix":"Jr.","given":"Joseph F","family":"Urban","sequence":"first","affiliation":[{"name":"U.S. Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Immunology and Disease Resistance Laboratory , Beltsville, MD 20705"},{"name":"Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Noben-Trauth","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20814"},{"name":"Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Schopf","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Immunology and Disease Resistance Laboratory , Beltsville, MD 20705"},{"name":"Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen B","family":"Madden","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20814"},{"name":"Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred D","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD 20814"},{"name":"Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2026020208142427800_R1","first-page":"1145","volume-title":"Int. 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