{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:26:06Z","timestamp":1770085566405,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We derived Rag2-deficient mice bearing two rearranged \u03b1\u03b2 TCR transgenes, one specific for the HY male Ag and the second specific for the gp33-41 peptide of lymphocytic choriomeningitis virus, both restricted to the MHC H-2Db class I molecule. We found that, in female double transgenic (DTg) mice, most CD8 T cells express only the TCR\u03b2 chain from the aHY transgene. By comparing the mRNA species for both \u03b2-chains, we observed that in T cells from DTg mice the aHY TCR\u03b2 chain transcripts are abundant, whereas the anti-lymphocytic choriomeningitis virus TCR\u03b2 chain transcripts are rare. In contrast to TCR\u03b2 chain expression, most of the T cells from DTg mice express two TCR\u03b1 chains. We examined the thymus selection of the dual-receptor CD8 T cells in the presence of self-Ag. We found that the presence of a second TCR\u03b1 chain allows a significant number of CD8 T cells expressing a self-reactive receptor to escape central deletion and migrate to the peripheral pools of male mice. Differences in TCR and coreceptor expression between female and male MoaHY and DTg mice suggest that peripheral T cell survival requires an optimal level of signaling, which implies a process of \u201cadaptation\u201d of lymphocyte populations to the host environment.<\/jats:p>","DOI":"10.4049\/jimmunol.167.11.6150","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:34Z","timestamp":1398024514000},"page":"6150-6157","source":"Crossref","is-referenced-by-count":9,"title":["CD8+ T Lymphocytes in Double \u03b1\u03b2 TCR Transgenic Mice. I. TCR Expression and Thymus Selection in the Absence or in the Presence of Self-Antigen"],"prefix":"10.1093","volume":"167","author":[{"given":"Nicolas","family":"Legrand","sequence":"first","affiliation":[{"name":"Lymphocyte Population Biology Unit, Unite\u0301 de Recherche Associe\u0301e, Centre National de la Recherche Scientifique, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio A","family":"Freitas","sequence":"additional","affiliation":[{"name":"Lymphocyte Population Biology Unit, Unite\u0301 de Recherche Associe\u0301e, Centre National de la Recherche Scientifique, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2026020208122610800_R1","first-page":"853","volume-title":"J. Exp. 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