{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:02:51Z","timestamp":1777474971854,"version":"3.51.4"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mice transgenic for the E7 tumor Ag of human papillomavirus type 16, driven from a keratin 14 promoter, express E7 in keratinocytes but not dendritic cells. Grafted E7-transgenic skin is not rejected by E7-immunized mice that reject E7-transduced transplantable tumors. Rejection of recently transplanted E7-transgenic skin grafts, but not of control nontransgenic grafts or of established E7-transgenic grafts, is induced by systemic administration of live or killed Listeria monocytogenes or of endotoxin. Graft recipients that reject an E7 graft reject a subsequent E7 graft more rapidly and without further L. monocytogenes exposure, whereas recipients of an E7 graft given without L. monocytogenes do not reject a second graft, even if given with L. monocytogenes. Thus, cross-presentation of E7 from keratinocytes to the adaptive immune system occurs with or without a proinflammatory stimulus, but proinflammatory stimuli at the time of first cross-presentation of Ag can determine the nature of the immune response to the Ag. Furthermore, immune effector mechanisms responsible for rejection of epithelium expressing a tumor Ag in keratinocytes are different from those that reject an E7-expressing transplantable tumor. These observations have implications for immunotherapy for epithelial cancers.<\/jats:p>","DOI":"10.4049\/jimmunol.167.11.6180","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:34Z","timestamp":1398024514000},"page":"6180-6187","source":"Crossref","is-referenced-by-count":36,"title":["Tolerance or Immunity to a Tumor Antigen Expressed in Somatic Cells Can Be Determined by Systemic Proinflammatory Signals at the Time of First Antigen Exposure"],"prefix":"10.1093","volume":"167","author":[{"given":"Ian H","family":"Frazer","sequence":"first","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"De Kluyver","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham R","family":"Leggatt","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yang Guo","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Dunn","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"White","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Cancer Research, University of Queensland , Brisbane ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Liem","sequence":"additional","affiliation":[{"name":"McArdle Institute for Cancer Research , Madison, WI 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lambert","sequence":"additional","affiliation":[{"name":"McArdle Institute for Cancer Research , Madison, WI 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2026020208144631000_R1","first-page":"133","volume-title":"Immunol. 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