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This finding implied a nonrandom distribution of IgG-producing B cells in the inflamed eye. In the present study, we compared the intraocular and systemic B cell responses of patients with ocular toxoplasmosis to a single Toxoplasma gondii Ag. Two series of C-terminally deleted recombinant T. gondii GRA-2 proteins were constructed to delineate IgG B cell epitopes of paired ocular and serum samples. Differences in epitope region recognition between the ocular and systemic compartment were detected in 9 of 13 patients. The difference in distribution of GRA-2 epitopes between paired samples is indicative of a local GRA-2 specific B cell population functionally different from the systemic GRA-2-specific B cell population. Our results suggest a selective activation of a subset of B cells locally in nonlymphoid tissue.<\/jats:p>","DOI":"10.4049\/jimmunol.167.11.6263","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:34Z","timestamp":1398024514000},"page":"6263-6269","source":"Crossref","is-referenced-by-count":19,"title":["Evidence for a Compartmentalized B Cell Response as Characterized by IgG Epitope Specificity in Human Ocular Toxoplasmosis"],"prefix":"10.1093","volume":"167","author":[{"given":"Vincent N A","family":"Klaren","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology, The Netherlands Ophthalmic Research Institute , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Peek","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, The Netherlands Ophthalmic Research Institute , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2026020208123527700_R1","first-page":"287","volume-title":"Curr. 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