{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:57:44Z","timestamp":1791313064393,"version":"4.3.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To elucidate the role of NKT cells in the host defense to cryptococcal infection, we examined the proportion of these cells, identified by the expression of CD3 and NK1.1, in lungs after intratracheal infection with Cryptococcus neoformans. This population increased on day 3 after infection, reached a peak level on days 6\u20137, and decreased thereafter. In V\u03b114 NKT cell-deficient mice, such increase was significantly attenuated. The proportion of V\u03b114 NKT cells, detected by binding to \u03b1-galactosylceramide-loaded CD1d tetramer, and the expression of V\u03b114 mRNA increased after infection with a similar kinetics. The delayed-type hypersensitivity response and differentiation of the fungus-specific Th1 cells was reduced in V\u03b114 NKT cell-deficient mice, compared with control mice. Additionally, elimination of this fungal pathogen from lungs was significantly delayed in V\u03b114 NKT cell-deficient mice. Production of monocyte chemoattractant protein (MCP)-1 in lungs, detected at both mRNA and protein levels, increased on day 1, reached a peak level on day 3, and decreased thereafter, which preceded the increase in NKT cells. Finally, the increase of total and V\u03b114+ subset of NKT cells after infection was significantly reduced in MCP-1-deficient mice. Our results demonstrated that NKT cells, especially V\u03b114+ subset, accumulated in a MCP-1-dependent manner in the lungs after infection with C. neoformans and played an important role in the development of Th1 response and host resistance to this fungal pathogen.<\/jats:p>","DOI":"10.4049\/jimmunol.167.11.6525","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:34Z","timestamp":1398024514000},"page":"6525-6532","source":"Crossref","is-referenced-by-count":127,"title":["Monocyte Chemoattractant Protein-1-Dependent Increase of V\u03b114 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection"],"prefix":"10.1093","volume":"167","author":[{"given":"Kazuyoshi","family":"Kawakami","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kinjo","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Uezu","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Yara","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Miyagi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Koguchi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Core Research for Evolutional Science and Technology Project, Department of Molecular Immunology, Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Core Research for Evolutional Science and Technology Project, Department of Molecular Immunology, Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Saito","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"2026020208144741200_R1","first-page":"543","volume-title":"Semin. 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