{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:08:36Z","timestamp":1791947316585,"version":"4.3.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>T cell IL-17 displays proinflammatory properties and is expressed in the synovium of patients with rheumatoid arthritis. Its contribution to the arthritic process has not been identified. Here, we show that blocking of endogenous IL-17 in the autoimmune collagen-induced arthritis model results in suppression of arthritis. Also, joint damage was significantly reduced. In contrast, overexpression of IL-17 enhanced collagen arthritis. Moreover, adenoviral IL-17 injected in the knee joint of type II collagen-immunized mice accelerated the onset and aggravated the synovial inflammation at the site. Radiographic and histologic analysis showed markedly increased joint destruction. Elevated levels of IL-1\u03b2 protein were found in synovial tissue. Intriguingly, blocking of IL-1\u03b1\u03b2 with neutralizing Abs had no effect on the IL-17-induced inflammation and joint damage in the knee joint, implying an IL-1 independent pathway. This direct potency of IL-17 was underscored in the unabated IL-17-induced exaggeration of bacterial cell wall-induced arthritis in IL-1\u03b2\u2212\/\u2212 mice. In conclusion, this data shows that IL-17 contributes to joint destruction and identifies an IL-1-independent role of IL-17. These findings suggest IL-17 to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.167.2.1004","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:17:55Z","timestamp":1398118675000},"page":"1004-1013","source":"Crossref","is-referenced-by-count":316,"title":["IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis"],"prefix":"10.1093","volume":"167","author":[{"given":"Erik","family":"Lubberts","sequence":"first","affiliation":[{"name":"Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A B","family":"Joosten","sequence":"additional","affiliation":[{"name":"Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Oppers","sequence":"additional","affiliation":[{"name":"Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liduine","family":"van den Bersselaar","sequence":"additional","affiliation":[{"name":"Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J J","family":"Coenen-de Roo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, NV Organon , Oss ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Department of Medicine, Louisiana State University Health Sciences Center , New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Schwarzenberger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Louisiana State University Health Sciences Center , New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fons A J","family":"van de Loo","sequence":"additional","affiliation":[{"name":"Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim B","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St. Radboud , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,7,15]]},"reference":[{"key":"2026020209111094500_R1","first-page":"2593","volume-title":"J. 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