{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:36:10Z","timestamp":1791668170917,"version":"4.3.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mycobacterium tuberculosis (MTB) induces vigorous immune responses, yet persists inside macrophages, evading host immunity. MTB bacilli or lysate was found to inhibit macrophage expression of class II MHC (MHC-II) molecules and MHC-II Ag processing. This report characterizes and identifies a specific component of MTB that mediates these inhibitory effects. The inhibitor was extracted from MTB lysate with Triton X-114, isolated by gel electroelution, and identified with Abs to be MTB 19-kDa lipoprotein. Electroelution- or immunoaffinity-purified MTB 19-kDa lipoprotein inhibited MHC-II expression and processing of both soluble Ags and Ag 85B from intact MTB bacilli. Inhibition of MHC-II Ag processing by either MTB bacilli or purified MTB 19-kDa lipoprotein was dependent on Toll-like receptor (TLR) 2 and independent of TLR 4. Synthetic analogs of lipopeptides from Treponema pallidum also inhibited Ag processing. Despite the ability of MTB 19-kDa lipoprotein to activate microbicidal and innate immune functions early in infection, TLR 2-dependent inhibition of MHC-II expression and Ag processing by MTB 19-kDa lipoprotein during later phases of macrophage infection may prevent presentation of MTB Ags and decrease recognition by T cells. This mechanism may allow intracellular MTB to evade immune surveillance and maintain chronic infection.<\/jats:p>","DOI":"10.4049\/jimmunol.167.2.910","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:17:55Z","timestamp":1398118675000},"page":"910-918","source":"Crossref","is-referenced-by-count":315,"title":["Toll-Like Receptor 2-Dependent Inhibition of Macrophage Class II MHC Expression and Antigen Processing by 19-kDa Lipoprotein of\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1093","volume":"167","author":[{"given":"Erika H","family":"Noss","sequence":"first","affiliation":[{"name":"Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH, 44106"},{"name":"Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH, 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rish K","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH, 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Sellati","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin D","family":"Radolf","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Belisle","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Colorado State University , Fort Collins, CO 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T","family":"Golenbock","sequence":"additional","affiliation":[{"name":"Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Henry","family":"Boom","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH, 44106"},{"name":"Tuberculosis Research Unit, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH, 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford V","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH, 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,7,15]]},"reference":[{"key":"2026020209063607800_R1","first-page":"1644","volume-title":"N. 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