{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:39:29Z","timestamp":1770086369260,"version":"3.49.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although production of specific Ab is a critical element of host defense, the presence of Ab in tissues leads to formation of immune complexes, which can trigger a type III Arthus reaction. Our studies on a mouse model of river blindness showed that Ab production is essential for recruitment of neutrophils and eosinophils to the cornea and for development of corneal opacification. In the current study, we determined the relative contribution of complement and Fc\u03b3R interactions in triggering immune complex-mediated corneal disease. Fc\u03b3R\u2212\/\u2212 mice, C3\u2212\/\u2212 mice, and immunocompetent control (B6\/129Sj) mice were immunized s.c. and injected intrastromally with Onchocerca volvulus Ags. Slit lamp examination showed that control mice, C3\u2212\/\u2212 mice, and control mice injected with cobra venom factor developed pronounced corneal opacification, whereas corneas of Fc\u03b3R\u2212\/\u2212 mice remained completely clear. Furthermore, recruitment of neutrophils and eosinophils to the corneal stroma was significantly impaired in Fc\u03b3R\u2212\/\u2212 mice, but not in C3\u2212\/\u2212 mice or cobra venom factor-treated mice. We therefore conclude that Fc\u03b3R-mediated cell activation, rather than complement activation, is the dominant pathway of immune complex disease in the cornea. These findings demonstrate a novel role for Fc\u03b3R interactions in mediating ocular inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.167.2.919","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:17:55Z","timestamp":1398118675000},"page":"919-925","source":"Crossref","is-referenced-by-count":17,"title":["A Dominant Role for Fc\u03b3 Receptors in Antibody-Dependent Corneal Inflammation"],"prefix":"10.1093","volume":"167","author":[{"given":"Laurie R","family":"Hall","sequence":"first","affiliation":[{"name":"Departments of Medicine and Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Pearlman","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland , Cleveland, OH 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,7,15]]},"reference":[{"key":"2026020209065646100_R1","first-page":"1052","volume-title":"Science","year":"1998"},{"key":"2026020209065646100_R2","first-page":"457","volume-title":"Annu. Rev. Immunol.","year":"1991"},{"key":"2026020209065646100_R3","first-page":"421","volume-title":"Annu. Rev. Immunol.","year":"1998"},{"key":"2026020209065646100_R4","first-page":"123","volume-title":"Am. J. Ophthalmol.","year":"1975"},{"key":"2026020209065646100_R5","first-page":"1430","volume-title":"Arch. Ophthalmol.","year":"1981"},{"key":"2026020209065646100_R6","first-page":"2119","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209065646100_R7","first-page":"775","volume-title":"Annu. Rev. Immunol.","year":"1994"},{"key":"2026020209065646100_R8","first-page":"1095","volume-title":"Science","year":"1994"},{"key":"2026020209065646100_R9","first-page":"2385","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209065646100_R10","first-page":"893","volume-title":"Mol. Immunol.","year":"1999"},{"key":"2026020209065646100_R11","first-page":"1065","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020209065646100_R12","first-page":"749","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020209065646100_R13","first-page":"S11","volume-title":"Ann. Trop. Med. Parasitol.","year":"1998"},{"key":"2026020209065646100_R14","first-page":"S65","volume-title":"Ann. Trop. Med. Parasitol.","year":"1998"},{"key":"2026020209065646100_R15","first-page":"445","volume-title":"Clin. Microbiol. Rev.","year":"1999"},{"key":"2026020209065646100_R16","first-page":"659","volume-title":"J. Infect. Dis.","year":"1995"},{"key":"2026020209065646100_R17","first-page":"802","volume-title":"Rev. Infect. Dis.","year":"1985"},{"key":"2026020209065646100_R18","first-page":"890","volume-title":"J. Infect. Dis.","year":"1983"},{"key":"2026020209065646100_R19","first-page":"570","volume-title":"Clin. Exp. Immunol.","year":"1980"},{"key":"2026020209065646100_R20","first-page":"447","volume-title":"Parasite Immunol.","year":"1987"},{"key":"2026020209065646100_R21","first-page":"931","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209065646100_R22","first-page":"1176","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"1998"},{"key":"2026020209065646100_R23","first-page":"5459","volume-title":"Infect. Immun.","year":"2000"},{"key":"2026020209065646100_R24","first-page":"4035","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209065646100_R25","first-page":"3856","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"2000"},{"key":"2026020209065646100_R26","first-page":"6975","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209065646100_R27","first-page":"593","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"1997"},{"key":"2026020209065646100_R28","first-page":"4970","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209065646100_R29","first-page":"519","volume-title":"Cell","year":"1994"},{"key":"2026020209065646100_R30","first-page":"11490","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1995"},{"key":"2026020209065646100_R31","first-page":"2212","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"1992"},{"key":"2026020209065646100_R32","first-page":"783","volume-title":"Infect. Immun.","year":"1984"},{"key":"2026020209065646100_R33","first-page":"237","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"1983"},{"key":"2026020209065646100_R34","first-page":"619","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209065646100_R35","first-page":"387","volume-title":"Immunity","year":"1996"},{"key":"2026020209065646100_R36","first-page":"5657","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209065646100_R37","first-page":"478","volume-title":"Arch. Ophthalmol.","year":"1982"},{"key":"2026020209065646100_R38","first-page":"1352","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"1988"},{"key":"2026020209065646100_R39","first-page":"123","volume-title":"Curr. Eye Res.","year":"1989"},{"key":"2026020209065646100_R40","first-page":"3199","volume-title":"Invest. Ophthalmol. Visual Sci.","year":"1993"},{"key":"2026020209065646100_R41","first-page":"4515","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020209065646100_R42","first-page":"7369","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209065646100_R43","first-page":"179","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020209065646100_R44","first-page":"635","volume-title":"Immunity","year":"1995"},{"key":"2026020209065646100_R45","first-page":"70","volume-title":"Nature","year":"1994"},{"key":"2026020209065646100_R46","first-page":"3826","volume-title":"Blood","year":"1997"},{"key":"2026020209065646100_R47","first-page":"672","volume-title":"J. Leukocyte Biol.","year":"1994"},{"key":"2026020209065646100_R48","first-page":"1871","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209065646100_R49","first-page":"487","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020209065646100_R50","first-page":"95","volume-title":"Int. Arch. Allergy Immunol.","year":"1999"},{"key":"2026020209065646100_R51","first-page":"85","volume-title":"Annu. Rev. Med.","year":"1993"},{"key":"2026020209065646100_R52","first-page":"207","volume-title":"Int. Arch. Allergy Immunol.","year":"1996"},{"key":"2026020209065646100_R53","first-page":"785","volume-title":"J. Exp. Med.","year":"1997"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/167\/2\/919\/62544483\/919.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/167\/2\/919\/62544483\/919.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:08:50Z","timestamp":1770041330000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/167\/2\/919\/8025244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,7,15]]},"published-print":{"date-parts":[[2001,7,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.167.2.919","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,7]]},"published":{"date-parts":[[2001,7]]}}}