{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:42:53Z","timestamp":1772887373725,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been reported recently that the bacterial respiratory pathogen Chlamydia \u00a0pneumoniae is present in the cerebrospinal fluid of a subset of multiple sclerosis (MS) patients. However, it is not known whether this organism is a causative agent of MS, or merely an opportunistic pathogen that takes advantage of a disease process initiated by some other means. We report identification of a 20-mer peptide from a protein specific to C. pneumoniae which shares a 7-aa motif with a critical epitope of myelin basic protein, a major CNS Ag targeted by the autoimmune response in MS. This bacterial peptide induces a Th1 response accompanied by severe clinical and histological experimental autoimmune encephalomyelitis in Lewis rats, a condition closely reflective of many aspects of MS. Studies with peptide analogues suggest that different populations of encephalitogenic T cells are activated by the C. pneumoniae and myelin basic protein Ags. Mild experimental autoimmune encephalomyelitis was also observed when rats were immunized with sonicated C. pneumoniae in CFA.<\/jats:p>","DOI":"10.4049\/jimmunol.167.3.1803","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:31:49Z","timestamp":1398123109000},"page":"1803-1808","source":"Crossref","is-referenced-by-count":44,"title":["A\n                    <i>Chlamydia<\/i>\n                    \u00a0\n                    <i>pneumoniae<\/i>\n                    -Specific Peptide Induces Experimental Autoimmune Encephalomyelitis in Rats"],"prefix":"10.1093","volume":"167","author":[{"given":"Derek C","family":"Lenz","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie B","family":"Conant","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert A","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herve\u0301 C","family":"Ge\u0301rard","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A","family":"Whittum-Hudson","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"},{"name":"Department of Internal Medicine, Wayne State University School of Medicine , Detroit, MI 48201"},{"name":"Department of Ophthalmology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan P","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H","family":"Swanborg","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"2026020209134484400_R1","first-page":"579","volume-title":"Annu. 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